June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Structure-Function Associations between Novel Contrast Sensitivity Function (CSF) Testing and Widefield Swept-Source Optical Coherence Tomography Angiography (WF SS-OCTA) in Diabetic Macular Edema (DME)
Author Affiliations & Notes
  • Grace Baldwin
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Filippos Vingopoulos
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Itika Garg
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Jade Yunkyung Moon
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Rebecca Zeng
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Ying Cui
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China
  • Raviv Katz
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Rongrong Le
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Wenzhou Medical University Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Edward S Lu
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Diane N Sayah
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Zakariyya Hassan
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Deeba Husain
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • John B Miller
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
    Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Grace Baldwin None; Filippos Vingopoulos None; Itika Garg None; Jade Moon None; Rebecca Zeng None; Ying Cui None; Raviv Katz None; Rongrong Le None; Edward Lu None; Diane Sayah None; Zakariyya Hassan None; Deeba Husain Allergen, Genetech, Omeicos Therapeutics, Code C (Consultant/Contractor), National Eye Institute, Lions VisionGift, Commonwealth Grant, Lions International, Syneos LLC, Macular Society, Code F (Financial Support); John Miller Alcon, Allergan, Carl Zeiss, Sunovion, Genentech, Code C (Consultant/Contractor)
  • Footnotes
    Support  Lions International Fund (Grant 530125 and 530869)
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2502 – F0228. doi:
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      Grace Baldwin, Filippos Vingopoulos, Itika Garg, Jade Yunkyung Moon, Rebecca Zeng, Ying Cui, Raviv Katz, Rongrong Le, Edward S Lu, Diane N Sayah, Zakariyya Hassan, Deeba Husain, John B Miller; Structure-Function Associations between Novel Contrast Sensitivity Function (CSF) Testing and Widefield Swept-Source Optical Coherence Tomography Angiography (WF SS-OCTA) in Diabetic Macular Edema (DME). Invest. Ophthalmol. Vis. Sci. 2022;63(7):2502 – F0228.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To elucidate the relationship between CSF and WF SS-OCTA metrics in patients with DME.

Methods : This cross-sectional prospectively recruited observational study included 53 eyes of 37 patients with DME imaged with WF SS-OCTA (PLEX® Elite 9000, Carl Zeiss Meditec) and tested for CSF with the Active Learning Quantitative CSF (qCSF) Manifold Contrast Vision Meter (Adaptive Sensory Technology) from November 2018 to March 2021. Functional outcomes included Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity (VA), and the following qCSF metrics: Area under the Log CSF (AULCSF), contrast acuity (CA), and contrast sensitivity thresholds at 1 to 18 cycles per degree (cpd). The ARI Network (Zeiss Portal v5.4) was used to quantify vessel density (VD) and vessel skeleton density (VSD) in the superficial (SCP) and deep (DCP) capillary plexus and whole retina, as well as foveal avascular zone (FAZ) area, circularity, and perimeter on 3x3 mm, 6x6 mm, and 12x12 mm OCTA images. Mixed effects multivariate regression analyses were performed.

Results : In our DME cohort, VA and contrast sensitivity (CS) outcomes were strongest associated with vascular metrics measured on 3x3 mm OCTA images compared to 6x6 mm and 12x12 mm images. While controlling for age and lens status, regression analyses revealed worse LogMAR VA was significantly associated with decreased SCP VD (β = -0.049, p = 0.026) and VSD (β = -2.562, p = 0.026) on 3x3 mm images. Among the CS outcomes, decreased AULCSF, CA, and CS thresholds at 1.5, 3, and 6 cpd were significantly associated with decreased SCP VSD (β = 3.533, p = 0.020; β = 2.826, p = 0.029; β = 2.629, p = 0.035; β = 3.590, p = 0.033; β = 4.672, p = 0.023, respectively). Decreased CS thresholds at 6 cpd was also significantly associated with SCP VD (β = 0.080, p = 0.043). While VA was not significantly associated with FAZ circularity, decreased CS thresholds at 1 and 1.5 cpd were significantly associated with decreased FAZ circularity (β = 0.567, p = 0.028; β = 0.669, p = 0.026, respectively).

Conclusions : We demonstrate novel structure-function associations in patients with DME leveraging a novel CSF device and WF SS-OCTA. Our results suggest that decreases in VD and VSD in the SCP of DME patients may be associated with larger changes in contrast sensitivity than in VA.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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