June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Greater physical activity is associated with neuroretinal thinning in glaucomatous and normative cohorts
Author Affiliations & Notes
  • Ella Claire Berry
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Henry Marshall
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Sean Mullany
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Santiago Diaz Torres
    QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
  • Joshua Schmidt
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Daniel Thomson
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Mark Hassall
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Stewart R Lake
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Richard A Mills
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • John Landers
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Stuart MacGregor
    QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
  • Robert Casson
    The University of Adelaide Discipline of Ophthalmology and Visual Sciences, Adelaide, South Australia, Australia
  • Owen Siggs
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
  • Jamie E Craig
    Ophthalmology, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia
  • Footnotes
    Commercial Relationships   Ella Berry None; Henry Marshall None; Sean Mullany None; Santiago Diaz Torres None; Joshua Schmidt None; Daniel Thomson None; Mark Hassall None; Stewart Lake None; Richard Mills None; John Landers None; Stuart MacGregor None; Robert Casson None; Owen Siggs None; Jamie Craig None
  • Footnotes
    Support  This work was funded by the National Health and Medical Research Council (NHMRC program grant APP1150144, and project grant APP1157571). OMS by a Snow Fellowship, and JEC by an NHMRC Practitioner Fellowship.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3490. doi:
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    • Get Citation

      Ella Claire Berry, Henry Marshall, Sean Mullany, Santiago Diaz Torres, Joshua Schmidt, Daniel Thomson, Mark Hassall, Stewart R Lake, Richard A Mills, John Landers, Stuart MacGregor, Robert Casson, Owen Siggs, Jamie E Craig; Greater physical activity is associated with neuroretinal thinning in glaucomatous and normative cohorts. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3490.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A multicohort investigation of the association between physical activity and longitudinal structural thinning in a cohort of early manifest primary open-angle glaucoma and between self-reported physical activity and total macular thickness in a population-based cohort.

Methods : In the discovery phase, 402 participants from the Progression Risk of Glaucoma: RElevant SNPs with Significant Association study wore a tri-axis accelerometer for a continuous seven-day period. Participants were split into tertiles based on the mean number of daily steps. The retrospective rate of Spectral-Domain Optical Coherence Tomography (SD-OCT) macular ganglion cell-inner plexiform layer (mGCIPL) was compared between tertiles. For the replication phase, self-reported exercise data from 29,708 individuals from the UK Biobank were cross-sectionally correlated with total macular thickness using SD-OCT imaging.

Results : Following adjustment for ocular and demographic covariates, the most active tertile was associated with a thicker cross-sectional mGCIPL (multivariate P=0.013) and demonstrated a 0.23μm/year slower rate of mGCIPL thinning (beta: 0.07μm/year/SD 95% CI 0.02-0.12 P=0.004). The most active tertile also exhibited a 2-fold lower risk of Guided Progression Analysis detected event based mGCIPL progression compared to the least active tertile (hazard ratio: 2.01 95% CI: 1.06-3.34; P=0.027). The magnitude of this association strengthened after adjusting for relevant cardiovascular and systemic comorbidities (0.08μm/year/SD 95% CI 0.03-0.13 P=0.003). A secondary analysis of cross-sectional visual fields demonstrated a higher daily step count was also associated with a higher mean deviation (less visual field damage) at time of accelerometer acquisition (beta: 0.24dB/SD 95% CI: 0.05-0.43 P=0.013). Assessment of the UK Biobank cohort revealed a positive correlation between self-reported days per week of exercise and total macular thickness (0.01SD/day 95% CI: 0.005-0.13 P<0.001).

Conclusions : Greater physical activity was associated with both a thicker cross-sectional mGCIPL and slower rate of mGCIPL thinning in primary open-angle glaucoma. Furthermore, greater physical exercise was associated with a thicker total macular thickness in the UK Biobank. These results implicate physical activity as a relevant covariate for neuroretinal degeneration, which may be relevant to glaucoma disease progression.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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