Abstract
Purpose :
To compare differences in outcomes following pars plana vitrectomy (PPV) for retinal detachment (RD) in the postoperative period between individuals on beta blockers (BB) and those who are not using BB.
Methods :
A retrospective cohort study was conducted using TriNetX (Cambridge, MA, USA), a federated electronic health records research network comprising multiple large health organizations in the United States. Patients who underwent PPV for RD were identified by CPT code and stratified into BB use and non-BB use. Cohorts were matched for age, gender, and medical comorbidities (essential hypertension, diabetes mellitus, cerebrovascular disease, heart failure, nicotine dependence, alcohol related disorders, and body mass index). The primary outcomes were: Vitreous hemorrhage, choroidal hemorrhage, RD or RD with retinal break, iridocyclitis, retinal edema, cystoid macular edema, macular pucker, toxic maculopathy, intraoperative/postoperative complications, ischemic optic neuropathy, glaucoma, cataract strabismus, hemorrhage of orbit, corneal edema, dry eye syndrome, central retinal vein occlusion (CRVO,) central retinal artery occlusion (CRAO.) One-year outcomes were compared between the cohorts after propensity score matching using logistic regression and greedy nearest-neighbor matching algorithm.
Results :
A total of 17,388 patients were included in analysis with 8,694 in each of the BB use and non-BB use cohorts after propensity matching.
The BB cohort had a significant greater risk of developing vitreous hemorrhage (RR, 1.16; 95% CI, 1.1-1.22), and cystoid macular degeneration (RR, 1.11; 95% CI, 1.0-1.22). No significant difference was seen in rate of development of choroidal hemorrhage, RD or RD with retinal break, Iridocyclitis, retinal edema, macular pucker, toxic maculopathy, intraoperative/postoperative complications, ischemic optic neuropathy, glaucoma, cataract, strabismus, hemorrhage of orbit, corneal edema, dry eye syndrome, CRVO and CRAO between the BB and non-BB use cohorts.
Conclusions :
Betablocker use is an important consideration when discussing risks during preoperative counseling and evaluating for postoperative complications following PPV for RD. Patients using betablockers were more likely to develop vitreous hemorrhage and cystoid macular edema.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.