June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Comparative analysis in outcomes follow pars plana vitrectomy in patients on beta blockers vs those who are not on beta blockers in the 1-year postoperative period: a multicenter electronic medical record cohort study.
Author Affiliations & Notes
  • Daniel Kulman
    Ophthalmology, George Washington University Medical Faculty Associates, Washington, District of Columbia, United States
  • Haig Pakhchanian
    The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States
  • Rahul Raiker
    The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States
  • Sinan Akosman
    The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States
  • Suveera Dang
    Ophthalmology, George Washington University Medical Faculty Associates, Washington, District of Columbia, United States
  • Monica Dalal
    Ophthalmology, George Washington University Medical Faculty Associates, Washington, District of Columbia, United States
  • Footnotes
    Commercial Relationships   Daniel Kulman None; Haig Pakhchanian None; Rahul Raiker None; Sinan Akosman None; Suveera Dang None; Monica Dalal None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3440 – F0340. doi:
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      Daniel Kulman, Haig Pakhchanian, Rahul Raiker, Sinan Akosman, Suveera Dang, Monica Dalal; Comparative analysis in outcomes follow pars plana vitrectomy in patients on beta blockers vs those who are not on beta blockers in the 1-year postoperative period: a multicenter electronic medical record cohort study.. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3440 – F0340.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare differences in outcomes following pars plana vitrectomy (PPV) for retinal detachment (RD) in the postoperative period between individuals on beta blockers (BB) and those who are not using BB.

Methods : A retrospective cohort study was conducted using TriNetX (Cambridge, MA, USA), a federated electronic health records research network comprising multiple large health organizations in the United States. Patients who underwent PPV for RD were identified by CPT code and stratified into BB use and non-BB use. Cohorts were matched for age, gender, and medical comorbidities (essential hypertension, diabetes mellitus, cerebrovascular disease, heart failure, nicotine dependence, alcohol related disorders, and body mass index). The primary outcomes were: Vitreous hemorrhage, choroidal hemorrhage, RD or RD with retinal break, iridocyclitis, retinal edema, cystoid macular edema, macular pucker, toxic maculopathy, intraoperative/postoperative complications, ischemic optic neuropathy, glaucoma, cataract strabismus, hemorrhage of orbit, corneal edema, dry eye syndrome, central retinal vein occlusion (CRVO,) central retinal artery occlusion (CRAO.) One-year outcomes were compared between the cohorts after propensity score matching using logistic regression and greedy nearest-neighbor matching algorithm.

Results : A total of 17,388 patients were included in analysis with 8,694 in each of the BB use and non-BB use cohorts after propensity matching.
The BB cohort had a significant greater risk of developing vitreous hemorrhage (RR, 1.16; 95% CI, 1.1-1.22), and cystoid macular degeneration (RR, 1.11; 95% CI, 1.0-1.22). No significant difference was seen in rate of development of choroidal hemorrhage, RD or RD with retinal break, Iridocyclitis, retinal edema, macular pucker, toxic maculopathy, intraoperative/postoperative complications, ischemic optic neuropathy, glaucoma, cataract, strabismus, hemorrhage of orbit, corneal edema, dry eye syndrome, CRVO and CRAO between the BB and non-BB use cohorts.

Conclusions : Betablocker use is an important consideration when discussing risks during preoperative counseling and evaluating for postoperative complications following PPV for RD. Patients using betablockers were more likely to develop vitreous hemorrhage and cystoid macular edema.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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