June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Choroidal Vascularity Profile in Diabetic Eyes Using Wide Field Optical Coherence Tomography
Author Affiliations & Notes
  • Ramkailash Gujar
    Department of Medicine and Surgery, Section of Ophthalmology, Universita degli Studi di Perugia, Perugia, Umbria, Italy
  • Carlo Cagini
    Department of Medicine and Surgery, Section of Ophthalmology, Universita degli Studi di Perugia, Perugia, Umbria, Italy
  • Daniela Fruttini
    Department of Internal Medicine,University of Perugia, S. Maria della Misericordia Hospital, 06156, Perugia, Italy, Universita degli Studi di Perugia, Perugia, Umbria, Italy
  • Roberta Corbucci
    Department of Medicine and Surgery, Section of Ophthalmology, Universita degli Studi di Perugia, Perugia, Umbria, Italy
  • Mohammed Abdul Rasheed
    School of Optometry and Vision Science, University of Waterloo, Ontario, Canada, University of Waterloo, Waterloo, Ontario, Canada
  • Kiran Kumar Kumar Vupparaboina
    Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, USA, UPMC, Pittsburgh, Pennsylvania, United States
  • Cesare Mariotti
    Eye Clinic, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy, Universita Politecnica delle Marche, Ancona, Marche, Italy
  • Jay Chhablani
    Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, USA, UPMC, Pittsburgh, Pennsylvania, United States
  • Marco Lupidi
    Eye Clinic, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy, Universita Politecnica delle Marche, Ancona, Marche, Italy
  • Footnotes
    Commercial Relationships   Ramkailash Gujar None; Carlo Cagini None; Daniela Fruttini None; Roberta Corbucci None; Mohammed Abdul Rasheed None; Kiran Kumar Vupparaboina None; Cesare Mariotti None; Jay Chhablani None; Marco Lupidi None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3358 – F0167. doi:
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    • Get Citation

      Ramkailash Gujar, Carlo Cagini, Daniela Fruttini, Roberta Corbucci, Mohammed Abdul Rasheed, Kiran Kumar Kumar Vupparaboina, Cesare Mariotti, Jay Chhablani, Marco Lupidi; Choroidal Vascularity Profile in Diabetic Eyes Using Wide Field Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3358 – F0167.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report the wide-field choroidal vascularity up to the mid-equator area in diabetic retinopathy (DR) subjects using wide-field optical coherence tomography (WF-OCT).

Methods : This is an observational, cross-sectional study. WF-OCT images (55 degrees) were obtained using Spectralis HRA+OCT (Heidelberg Engineering, Germany) in extremes of gazes in all quadrants and manual montages were created to obtain wide field images up to mid equator. A previously reported semi-automated algorithm was used to calculate choroidal vascularity profile (CVI). Regression analysis was performed to identify the factors influencing CVI.

Results : Forty-seven eyes from 25 patients were enrolled in the study. The mean age was 68.4±10.6 years. The refractive error (spherical equivalent) ranged from -2.25 to +3.75 diopters. Most common DR grade among study subjects was moderate NPDR (29.41%) and 74.5% eyes had diabetic macular edema (DME). The mean CVI in the macular area (58.29±3.63) was significantly lower than in any of the other fundus areas (all p≤0.01). The maximum CVI was seen in the nasal region (66.60 ± 5.61), followed by temporal (65.69 ± 3.81), superior (65.01 ± 4.87), and inferior (63.80 ± 5.42). The vertical macular area had the least coefficient of variation (CV) of CVI (0.06) while the inferior quadrant had the highest CV (0.08).

Conclusions : The current study describes the CVI profile on WF-OCT in DR eyes upto mid-equator. The significant increase of the CVI compared to healthy subjects and its significant regional variations introduce this novel quantitative parameter as a reliable biomarker of the diabetes-induced choroidal microangiopathy.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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