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Hong Jiang, Ava-Gaye Simms, Silvia Delgado, Jeffrey Hernandez, Giovanni Gregori, Jianhua Wang; Retinal capillary function in patients with multiple sclerosis: 2-year follow-up. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3335 – F0144.
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To determine the retinal capillary function (the efficiency of blood flow transferring capacity of retinal capillary network) in patients with multiple sclerosis: 2-year follow-up.
A total of 22 patients (22 eyes) with RRMS were followed for a period of 27 ± 6 months. One eye of each subject was imaged at baseline and at follow-up. Retinal blood flow (RBF) was measured using a Retinal Function Imager and retinal capillary density (RCD, expressed as fractal dimension Dbox) was measured using optical coherence tomography angiography. The efficiency of blood flow transferring capacity of retinal capillary network retinal capillary function (RCF) was defined as the ratio of RBF to RCD.
RCF was 1.36 ± 0.26 nl/s/Dbox (mean ± SD) at baseline and significantly increased to 1.61 ± 0.36 nl/s/Dbox after training (P = 0.03), reflecting an increase of 19%. There were 15 study subjects without clinical and radiological disease activity during the follow-up period, while there were 8 subjects with disease activity. Further analysis showed that the significant increase of RCF (i.e. change 0.33 nl/s/Dbox, P = 0.042) occurred only in the subgroup without disease activity. The change in the subgroup with active disease was 0.08 nl/s/Dbox (P = 0.50).
This is the first prospective study to demonstrate an increased RCF in MS patients with stable disease at 2-year follow-up, suggesting a possible recovery of RCF which may be associated to an enhanced blood flow to the retina in these patients.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.
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