June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Retinal capillary function in patients with multiple sclerosis: 2-year follow-up
Author Affiliations & Notes
  • Hong Jiang
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, United States
    Neurology, University of Miami Miller School of Medicine, Florida, United States
  • Ava-Gaye Simms
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, United States
  • Silvia Delgado
    Neurology, University of Miami Miller School of Medicine, Florida, United States
  • Jeffrey Hernandez
    Neurology, University of Miami Miller School of Medicine, Florida, United States
  • Giovanni Gregori
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, United States
  • Jianhua Wang
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, United States
  • Footnotes
    Commercial Relationships   Hong Jiang None; Ava-Gaye Simms None; Silvia Delgado None; Jeffrey Hernandez None; Giovanni Gregori None; Jianhua Wang None
  • Footnotes
    Support  The work was supported by the National Multiple Sclerosis Society (RG-1506-04890), NIH Center Grant P30 EY014801, and a grant from Research to Prevent Blindness (RPB).
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3335 – F0144. doi:
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    • Get Citation

      Hong Jiang, Ava-Gaye Simms, Silvia Delgado, Jeffrey Hernandez, Giovanni Gregori, Jianhua Wang; Retinal capillary function in patients with multiple sclerosis: 2-year follow-up. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3335 – F0144.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the retinal capillary function (the efficiency of blood flow transferring capacity of retinal capillary network) in patients with multiple sclerosis: 2-year follow-up.

Methods : A total of 22 patients (22 eyes) with RRMS were followed for a period of 27 ± 6 months. One eye of each subject was imaged at baseline and at follow-up. Retinal blood flow (RBF) was measured using a Retinal Function Imager and retinal capillary density (RCD, expressed as fractal dimension Dbox) was measured using optical coherence tomography angiography. The efficiency of blood flow transferring capacity of retinal capillary network retinal capillary function (RCF) was defined as the ratio of RBF to RCD.

Results : RCF was 1.36 ± 0.26 nl/s/Dbox (mean ± SD) at baseline and significantly increased to 1.61 ± 0.36 nl/s/Dbox after training (P = 0.03), reflecting an increase of 19%. There were 15 study subjects without clinical and radiological disease activity during the follow-up period, while there were 8 subjects with disease activity. Further analysis showed that the significant increase of RCF (i.e. change 0.33 nl/s/Dbox, P = 0.042) occurred only in the subgroup without disease activity. The change in the subgroup with active disease was 0.08 nl/s/Dbox (P = 0.50).

Conclusions : This is the first prospective study to demonstrate an increased RCF in MS patients with stable disease at 2-year follow-up, suggesting a possible recovery of RCF which may be associated to an enhanced blood flow to the retina in these patients.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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