June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
High axial resolution optical coherence tomography images show important features in patients with age-related macular degeneration
Author Affiliations & Notes
  • Rosa Dolz-Marco
    Unit of Macula, Oftalvist, Valencia, Valencia, Spain
  • Roberto Gallego Pinazo
    Unit of Macula, Oftalvist, Valencia, Valencia, Spain
  • Footnotes
    Commercial Relationships   Rosa Dolz-Marco Heidelberg Engineering, Novartis, Roche, Code C (Consultant/Contractor), Novartis, Roche, IveriBIO, Celltrion, Code F (Financial Support); Roberto Gallego Pinazo Novartis, Roche, ORA clinical, Carl Zeiss Meditec, Code C (Consultant/Contractor), Novartis, Roche, IvericBIO, Celltrion, Code F (Financial Support)
  • Footnotes
    Support  NONE
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3331 – F0140. doi:
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    • Get Citation

      Rosa Dolz-Marco, Roberto Gallego Pinazo; High axial resolution optical coherence tomography images show important features in patients with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3331 – F0140.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To evaluate the clinical benefit of high axial resolution optical coherence tomography (OCT) images in patients diagnosed with age-related macular degeneration (AMD) using a research OCT prototype (High-Res OCT, Heidelberg Engineering, Germany) with 3 µm optical resolution.

Methods : Patients diagnosed with AMD undergoing routine macular evaluation were scheduled for High-Res OCT imaging. The examination included OCT, OCT angiography, fundus autofluorescence, and multispectral images acquired with commercially available OCT device (SPECTRALIS) and High-Res OCT images acquired using the research prototype. Findings observed on the High-Res OCT images were compared and correlated with the conventional OCT and multimodal approach.

Results : One-hundred eleven eyes of 63 patients were included. A better delineation of retinal layers was achieved with increased contrast between layers in the High-Res OCT images. The status of the outer retinal bands (external limiting membrane, photoreceptors ellipsoid and interdigitation zones) and the content of the retinal pigment epithelium (RPE) detachment both in neovascular and non-neovascular cases were better assessed in High-Res images when compared to conventional OCT. A significant split between the RPE layer and Bruch’s membrane was observed in the majority of cases (84%) in the foveal area and also extending throughout the macula and was not evident on conventional OCT.

Conclusions : High-Res OCT images provided a detailed representation of structures in the retina not seen with conventional OCT axial resolution (about 7 µm). A better delimitation between layers was observed, and better assessment of important biomarkers in AMD cases was achieved, which might be beneficial in the improvement of segmentation algorithms and clinical evaluation of these cases.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.


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