June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Comparing Bruch’s Membrane Opening, Intraocular pressure, and Pulsatile Ocular Blood Volume when in sitting and supine positions in Glaucomatous and Non-Glaucomatous eyes
Author Affiliations & Notes
  • Stephen BUMA
    The Ohio State University College of Medicine, Columbus, Ohio, United States
  • Nayasha S Madhan
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
  • Yanhui Ma
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
  • Ashraf Mahmoud
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Gloria Fleming
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Cynthia J Roberts
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Footnotes
    Commercial Relationships   Stephen BUMA None; Nayasha Madhan None; Yanhui Ma None; Ashraf Mahmoud None; Gloria Fleming None; Cynthia Roberts Ziemer Ophthalmic Systems AG, Code C (Consultant/Contractor), Oculus Optikgeräte GmbH, Code C (Consultant/Contractor), Heidelberg Engineering, Inc, Code R (Recipient)
  • Footnotes
    Support  NIH/NEI R01 EY027399
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3318 – F0127. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Stephen BUMA, Nayasha S Madhan, Yanhui Ma, Ashraf Mahmoud, Gloria Fleming, Cynthia J Roberts; Comparing Bruch’s Membrane Opening, Intraocular pressure, and Pulsatile Ocular Blood Volume when in sitting and supine positions in Glaucomatous and Non-Glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3318 – F0127.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To investigate Bruch’s Membrane Opening-Minimum Rim Width (BMO-MRW), Intraocular pressure (IOP) and Pulsatile Ocular Blood Volume (POBV) between glaucomatous and non-glaucomatous eyes in supine and sitting positions.

Methods : Cross-sectional, prospectively acquired data was used to evaluate 323 eyes of 181 healthy controls (NRL) and 66 eyes of 42 subjects diagnosed with primary open-angle glaucoma (GLA). BMO-MRW was measured using Flex-Arm Spectralis Optical Coherence Tomography (OCT) in both sitting and supine positions, as well as pneumatonometry to measure IOP and ocular pulse amplitude (OPA). A surrogate of POBV was calculated by dividing OPA by diastolic IOP. BMO-MRW in GLA and NRL were compared using ANCOVA with IOP as a co-variate. Univariate regression analyses were performed between BMO-MRW and IOP. Paired t-tests were included between sitting and supine positions. SAS statistical analysis software was used with p<0.05 as the significance threshold.

Results : BMO-MRW was significantly smaller in GLA eyes compared to NRL in the supine position (211 ± 60 µm vs 357 ± 61 µm; p<.001). IOP is negatively correlated to BMO-MRW in both sitting (R2=.08; p<.001) and supine (R2=.05; p<.001) positions only in NRL eyes. IOP increases significantly in supine position relative to sitting in both GLA (19±4mmHg vs 23±4mmHg; p<.001) and NRL groups (16±3mmHg vs 21±3mmHg; p<.001). POBV surrogate is significantly lower in the supine position compared to sitting in both GLA (.10±.03 vs .12±.05; p<.001) and NRL (.10±.04 vs .14±.06; p<.001) cohorts.

Conclusions : It is known that BMO-MRW is smaller in glaucoma than normal in the sitting position, and the current study confirms this relationship also exists in the supine position with higher IOP. In addition, this study shows higher IOP is associated with smaller BMO-MRW only in NRL. It is also known that IOP increases with extended time in the supine position during sleep. Although there is no immediate change in BMO-MRW between sitting and supine positions, further studies are warranted to determine if BMO-MRW is affected by extended periods of time in the supine position as IOP increases. Additionally, POBV decreases relative to sitting in both groups indicating less perfusion, which may represent additional risk to the glaucomatous eye during extended periods in the supine position.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×