June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
In Vivo Relationship of Corneal and Scleral Stiffness with Bruch’s Membrane Opening Minimum Rim Width in Glaucomatous versus Non-Glaucomatous Eyes
Author Affiliations & Notes
  • Nayasha S Madhan
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
  • Stephen Buma
    The Ohio State University College of Medicine, Columbus, Ohio, United States
  • Yanhui Ma
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
  • Ashraf Mahmoud
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
    Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Gloria Fleming
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
    Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Cynthia J Roberts
    Ophthalmology and Visual Sciences, The Ohio State University College of Medicine, Columbus, Ohio, United States
    Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States
  • Footnotes
    Commercial Relationships   Nayasha Madhan None; Stephen Buma None; Yanhui Ma None; Ashraf Mahmoud None; Gloria Fleming None; Cynthia Roberts Ziemer Ophthalmic Systems AG, Code C (Consultant/Contractor), Oculus Optikgeräte GmbH, Code C (Consultant/Contractor), Heidelberg Engineering, Inc, Code R (Recipient)
  • Footnotes
    Support  NIH/NEI R01 EY027399
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3310 – F0119. doi:
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    • Get Citation

      Nayasha S Madhan, Stephen Buma, Yanhui Ma, Ashraf Mahmoud, Gloria Fleming, Cynthia J Roberts; In Vivo Relationship of Corneal and Scleral Stiffness with Bruch’s Membrane Opening Minimum Rim Width in Glaucomatous versus Non-Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3310 – F0119.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the relationship between Bruch’s Membrane Opening Minimum Rim Width (BMO) and ocular biomechanics in glaucomatous and non-glaucomatous eyes.

Methods : A cross-sectional study of prospectively acquired data was used to evaluate 323 eyes of 181 healthy controls (NRL) and 66 eyes of 42 subjects diagnosed with primary open angle glaucoma (GLA). Biomechanical response was characterized using the Corvis ST by comparing the stiffness parameters at first applanation (SP-A1) to indicate corneal stiffness and the stiffness parameter at highest concavity (SP-HC) to quantify scleral stiffness in the seated position. Spectralis OCT imaging was used to measure BMO. Pneumatonometry was used to measure intraocular pressure (IOP) and ocular pulse amplitude (OPA). BMO was compared to IOP by group with univariate regression analysis. BMO was also compared between GLA and NRL using ANCOVA with IOP as a co-variate. Finally, two multiple regression analyses were performed with BMO as the dependent variable, and IOP, age and either SP-A1 or SP-HC as the independent variables, using SAS statistical analysis software with p<0.05 as the significance threshold.

Results : Global BMO was significantly smaller in GLA compared to NRL eyes (211 ± 59 µm vs 358 ± 60 µm; p<0.001), and significantly negatively related to IOP only in NRL (p<0.001). Both corneal and scleral stiffness were significantly greater in GLA (SP-A1 p<0.001; SP-HC p<0.027). The two multiple regression analyses showed a significant, negative relationship of BMO with SP-A1 (p<0.001, R2=0.088) and SP-HC (p<0.001, R2=0.078) in NRL but not in GLA.

Conclusions : BMO decreases as IOP increases in NRL, but IOP has no effect on the significantly smaller BMO in GLA. As corneal and/or scleral stiffness increases, the BMO decreases in NRL but has no effect in the significantly stiffer GLA. These in vivo findings indicate that increasing stiffness may be an additional risk factor to increasing IOP for decreased BMO, and to the development of glaucomatous damage. Our results provide insight into the role of ocular biomechanics in glaucoma and identify parameters that may increase the risk of glaucoma development.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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