June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
CONJUNCTIVAL KERATOACANTHOMA: A CLINICAL AND HISTOPATHOLOGICAL CASE SERIES
Author Affiliations & Notes
  • David Monroy
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Mike Zein
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Nandini Venkateswaran
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Jared Matthews
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Pedro Monsalve
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Ann Quann
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Anat Galor
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • George Elgart
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Carol L. Karp
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Sander R Dubovy
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   David Monroy None; Mike Zein None; Nandini Venkateswaran None; Jared Matthews None; Pedro Monsalve None; Ann Quann None; Anat Galor None; George Elgart None; Carol Karp None; Sander Dubovy None
  • Footnotes
    Support  NIH Center Core Grant P30EY014801, RPB Unrestricted Award, Dr. Ronald and Alicia Lepke Grant, The Lee and Claire Hager Grant, The Robert Farr Family Grant, The Grant and Diana Stanton-Thornbrough ,The Robert Baer Family Grant, The Roberto and Antonia Menendez Grant, The Emilyn Page and Mark Feldberg Grant, The Calvin and Flavia Oak Support Fund, The Robert Farr Family Grant, The Jose Ferreira de Melo Grant, The Richard and Kathy Lesser Grant, The Honorable A. Jay Cristol Grant, The Michele and Ted Kaplan Grant and the Richard Azar Family Grant(institutional grants), Carol Sofer Grant.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3151 – A0046. doi:
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      David Monroy, Mike Zein, Nandini Venkateswaran, Jared Matthews, Pedro Monsalve, Ann Quann, Anat Galor, George Elgart, Carol L. Karp, Sander R Dubovy; CONJUNCTIVAL KERATOACANTHOMA: A CLINICAL AND HISTOPATHOLOGICAL CASE SERIES. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3151 – A0046.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Conjunctival keratoacanthomas are rare, low-grade, hyperkeratotic crateriform tumors. The purpose of this study was to investigate the clinical, histopathological, immunohistochemical, and diagnostic imaging results that define conjunctival keratoacanthomas.

Methods : Retrospective chart reviews of 8 patients with pathologically confirmed conjunctival keratoacanthomas were performed. The demographics, clinical history, diagnostic testing (slit-lamp photography, high-resolution anterior segment optical coherence tomography, and high-resolution ultrasound biomicroscopy images), treatment modalities, histopathology, immunohistochemical testing, visual outcomes, and recurrences were extracted after identifying the patients in a database search of the Florida Lions Ocular Pathology Laboratory records.

Results : The mean age of the 8 identified patients was 54.5 years + 22.4 years. 75% (6/8) of patients were male and 62.5% (5/8) were of Hispanic ethnicity. All lesions were rapidly growing, white nodular lesions located on the bulbar conjunctiva located in the interpalpebral exposure zone. All lesions were surgically excised, and two underwent partial spontaneous resolution prior to surgery. No cases recurred at up to one year of follow-up. A prominent keratin-filled cup-shaped lesion with faulty maturational sequencing that extended full thickness with variably pale cytoplasm and foci of dyskeratosis and hyperkeratosis was present on histopathology in all cases. Hyper-reflective, thickened epithelium often overlying disorganized subepithelial tissue was seen on high-resolution anterior segment optical coherence tomography.

Conclusions : Conjunctival keratoacanthomas are rare lesions of the ocular surface with distinct clinical, histopathologic, and diagnostic features. Further research is required to better understand the clinical course and optimal treatment approach of this rare condition.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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