June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Accommodation with simulated contact lenses in Myopes
Author Affiliations & Notes
  • Shrilekha Vedhakrishnan
    Institute of Optics, Visual Optics and Biophotonics lab (VIOBIO), Consejo Superior de Investigaciones Cientificas, Madrid, Madrid, Spain
  • Alberto de Castro
    Institute of Optics, Visual Optics and Biophotonics lab (VIOBIO), Consejo Superior de Investigaciones Cientificas, Madrid, Madrid, Spain
  • Maria Vinas
    Institute of Optics, Visual Optics and Biophotonics lab (VIOBIO), Consejo Superior de Investigaciones Cientificas, Madrid, Madrid, Spain
    Wellmen Center for Photomedicine, Harvard University, Cambridge, Massachusetts, United States
  • SARA AISSATI
    Institute of Optics, Visual Optics and Biophotonics lab (VIOBIO), Consejo Superior de Investigaciones Cientificas, Madrid, Madrid, Spain
  • Susana Marcos
    Institute of Optics, Visual Optics and Biophotonics lab (VIOBIO), Consejo Superior de Investigaciones Cientificas, Madrid, Madrid, Spain
    The Institute of Optics; Flaum Eye Institu, University of Rochester, Rochester, New York, United States
  • Footnotes
    Commercial Relationships   Shrilekha Vedhakrishnan None; Alberto de Castro OCT, Code P (Patent); Maria Vinas 2EyesVision, Code C (Consultant/Contractor); SARA AISSATI None; Susana Marcos Johnson & Johnson, Code C (Consultant/Contractor), 2EyesVision, Code I (Personal Financial Interest)
  • Footnotes
    Support  Spanish Government FIS2017-84753-R , PID2020-115191RB-I00 & Juan de la Cierva (IJC2018-037508-I); EU Marie Sklodowska-Curie grant agreements No 675137 (MyFun);Marie Sklodowska-Curie Actions (H2020 MSCA IF GF 2019 MYOMICRO 893557);Spanish Government FPU16/01944;NIH NIE P30EY 001319; Unrestricted Funds Research to Prevent Blindness, NY
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3063 – F0535. doi:
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    • Get Citation

      Shrilekha Vedhakrishnan, Alberto de Castro, Maria Vinas, SARA AISSATI, Susana Marcos; Accommodation with simulated contact lenses in Myopes. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3063 – F0535.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : There is an association between myopia progression and near work that has led to speculation that the larger accommodative lags reported in myopes may be a factor or an effect in progression. We evaluated the impact of contact lenses design and addition on the accommodative behavior in myopes

Methods : A Hartmann-Shack wavefront sensor in an Adaptive Optics (AO) visual simulator was used to measure the wavefront aberrations in 5 myopic subjects (MS, 27±2yrs; spherical error: -2.25±0.3D) while viewing a stimulus changing between 0-6D (ramdomized,1D steps) through multifocal/bifocal corrections, under natural viewing conditions, measurements were repeated 5times for repeatability. The corrections were simulated with a Spatial Light Modulator or a deformable mirror and the accommodative response was calculated using the defocus term, spherical aberration Z (4,0) of the wavefront aberrations.7 conditions were tested: NoLens (NL) and when viewing through aspheric designs of high (2.50D, HA) and medium add (1.75D, MA), bifocal (4mm central zone, 2.5 D) - center distance (CD), center near (CN) and with inducing positive and negative 1µm spherical aberration (PSA, NSA) using deformable mirror were measured.

Results : There was a systematic decrease in pupil diameter with accommodation, the average slope was -0.19/-0.25/-0.15/-0.11/-0.16/-0.11/-0.15mm/D for NL/PSA/NSA/HA/MA/CN/CD. The average slope of change of spherical aberration with accommodative demand (0-6D) shifted to more negative values for NL/PSA/CD -0.02/-0.07/-0.005µm/D whereas the slope of this change reduced for NSA/HA/MD/CN 0.04/0.01/0.02/0.01µm/D. The accommodative lag computed considering only defocus and 4th order spherical aberration showed higher amount of lag with PSA (0.04D) than NL (0.03D) and the least with MA (0.02D), some conditions caused a lead of accommodation NSA(-0.041D).

Conclusions : AO simulators are useful tools to simulate multifocal contact lenses. The performance and interaction of these lenses are driven by individual presence or absence of high-order aberrations which alters the accommodative response. Near additions in some cases can reduce the accommodative lag and convert them to leads.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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