June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Recent clinical features of uveitis in southwest region of Japan
Author Affiliations & Notes
  • Kenichiro Asahara
    Dept. of Ophthalmology, Kyushu University, Japan
  • Nobuyo Yawata
    Dept. of Ophthalmology, Kyushu University, Japan
  • Eiichi Hasegawa
    Dept. of Ophthalmology, Kyushu University, Japan
  • Satoshi Yamana
    Dept. of Ophthalmology, Kyushu University, Japan
  • Mariko Shirane
    Dept. of Ophthalmology, Kyushu University, Japan
  • Akira Hayashida
    Dept. of Ophthalmology, Kyushu University, Japan
  • Keiko Yoshitomi
    Dept. of Ophthalmology, Kyushu University, Japan
  • Takuma Fukui
    Dept. of Ophthalmology, Kyushu University, Japan
  • Natsuki Himeno
    Dept. of Ophthalmology, Kyushu University, Japan
  • Takako Ito
    Dept. of Ophthalmology, Kyushu University, Japan
  • Atsunobu Takeda
    Dept. of Ophthalmology, Kyushu University, Japan
  • Koh-Hei Sonoda
    Dept. of Ophthalmology, Kyushu University, Japan
  • Footnotes
    Commercial Relationships   Kenichiro Asahara None; Nobuyo Yawata None; Eiichi Hasegawa None; Satoshi Yamana None; Mariko Shirane None; Akira Hayashida None; Keiko Yoshitomi None; Takuma Fukui None; Natsuki Himeno None; Takako Ito None; Atsunobu Takeda None; Koh-Hei Sonoda None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3936 – A0479. doi:
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      Kenichiro Asahara, Nobuyo Yawata, Eiichi Hasegawa, Satoshi Yamana, Mariko Shirane, Akira Hayashida, Keiko Yoshitomi, Takuma Fukui, Natsuki Himeno, Takako Ito, Atsunobu Takeda, Koh-Hei Sonoda; Recent clinical features of uveitis in southwest region of Japan. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3936 – A0479.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the recent trends of uveitis in Kyushu University Hospital, the regional center for uveitis care in southwestern Japan.

Methods : We retrospectively investigated the medical records of patients with uveitis who first visited Kyushu University Hospital between April 2015 and March 2020. Clinical data obtained included age, gender, diagnosis, anatomical location of ocular inflammation (anterior, intermediate, posterior, pan). We compared them with the previous studies of our facility and the national survey (Jpn J Ophthalmol. 2021).

Results : The total number of new patients with uveitis who visited Kyushu University Hospital was 790 (327 males, 463 females) accounting for 4.8% of all the new cases in our eye clinic. Mean age was 52.9 ± 19.8 years (men 52.0 years, women 53.5 years). The frequency of anterior uveitis, intermediate uveitis, posterior uveitis, and panuveitis were 23.0%, 3.0%, 9.9%, and 64.1%, respectively. Definite diagnoses were made in 506 cases (64.1%). In contrast to the national survey, Vogt-Koyanagi-Harada disease was the most frequent (11.4%), followed by sarcoidosis (9.4%), scleritis (5.8%), acute anterior uveitis (5.1%), herpetic iridocyclitis (4.9%), Behçet’s disease (4.7%), malignant diseases (3.2%), acute retinal necrosis (3.2%), cytomegalovirus (CMV) retinitis (2.2%), and human T lymphotropic virus type 1 (HTLV-1)-associated uveitis (1.8%). Four of the top 10 most frequent uveitis were infectious in our study, whereas only 2 in the national survey. When compared with our previous reports, the present study showed increasing trends in Vogt-Koyanagi-Harada disease, scleritis, herpetic iridocyclitis, acute retinal necrosis, CMV retinitis, and malignant diseases. Among the herpetic iridocyclitis, CMV was found to be the most frequent agent. Behçet’s disease and HTLV-1-associated uveitis were decreasing. Among the patients over 70 years old, intraocular lymphoma was the second most frequent disorder after sarcoidosis.

Conclusions : Although southwestern Japan has been an endemic area of HTLV-1, frequency of HTLV-1-associated uveitis is decreasing, reflecting on improvements in public health. Increases of CMV-associated diseases and malignant diseases, commonly observed in this study and the national survey, seem to be associated with the development of the diagnostics.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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