June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Optical Coherence Tomography Angiography Compared with Indocyanine Green Angiography in Uveitis
Author Affiliations & Notes
  • Aman Kumar
    National Eye Institute, Bethesda, Maryland, United States
    Albany Medical College, Albany, New York, United States
  • Wijak Kongwattananon
    National Eye Institute, Bethesda, Maryland, United States
    Chulalongkorn University, Bangkok, Bangkok, Thailand
  • H Nida Sen
    National Eye Institute, Bethesda, Maryland, United States
  • Shilpa Kodati
    National Eye Institute, Bethesda, Maryland, United States
  • Footnotes
    Commercial Relationships   Aman Kumar None; Wijak Kongwattananon None; H Nida Sen None; Shilpa Kodati None
  • Footnotes
    Support  National Eye Institute Intramural Research Program
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3933 – A0476. doi:
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      Aman Kumar, Wijak Kongwattananon, H Nida Sen, Shilpa Kodati; Optical Coherence Tomography Angiography Compared with Indocyanine Green Angiography in Uveitis. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3933 – A0476.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare hypocyanescent lesions on Indocyanine Green Angiography (ICGA) to choriocapillaris flow deficits on Optical Coherence Tomography Angiography (OCTA) in eyes with posterior and panuveitis.

Methods : En-face 6x6 OCTA images of the choriocapillaris and mid-phase ICGA images from patients with posterior and panuveitis were retrospectively reviewed and images were quantitatively compared using ImageJ. Using feature-based image registration, the OCTA image was mapped to the ICGA image. Each lesion was outlined, binarized and then overlapped to determine the Dice similarity coefficient (DSC). Bland-Altman analysis was used to compare measurements of lesion morphology including four primary features: lesion number (LN), lesion density (LD%), lesion circularity (LCi) and mean lesion size (MLS). Lastly, eyes were divided into clinically quiet group and an active group and subgroup comparison of DSC values were conducted.

Results : A total of 36 eyes from 26 patients were analyzed. The overall agreement between lesions from ICG and OCTA was classified as good (mean DSC = 0.744; 95% confidence interval [0.679, 0.809]). No significant differences between the mean LN, LD%, LCi, and MLS were noted. LN and LCi were slightly higher in ICGA compared with OCTA. LD% and MLS were slightly higher on OCTA compared with ICGA. Eyes with active disease (0.642 ± 0.175, n = 12) had a significantly lower DSC compared to those eyes with quiet disease (0.789 ± 0.183, n = 24) (P = 0.028).

Conclusions : OCTA appears to be a reasonably accurate measure of choriocapillaris flow deficits in patients with posterior and panuveitis compared to hypocyanescent lesions on ICGA.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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