June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Utility of Fluorescein Angiography in Patients with Anterior Uveitis
Author Affiliations & Notes
  • Alexander Zeleny
    National Eye Institute, Bethesda, Maryland, United States
    Georgetown University Medical Center, Washington, District of Columbia, United States
  • Enny Oyeniran
    National Eye Institute, Bethesda, Maryland, United States
  • Shilpa Kodati
    National Eye Institute, Bethesda, Maryland, United States
  • Footnotes
    Commercial Relationships   Alexander Zeleny None; Enny Oyeniran None; Shilpa Kodati None
  • Footnotes
    Support  NEI Intramural Research Program
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3929 – A0472. doi:
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      Alexander Zeleny, Enny Oyeniran, Shilpa Kodati; Utility of Fluorescein Angiography in Patients with Anterior Uveitis. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3929 – A0472.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the utility of performing ultra-wide field fluorescein angiography (FA) in patients with anterior uveitis and to investigate the frequency of retinal vascular leakage in patients with anterior uveitis.

Methods : A retrospective chart review was conducted. Inclusion criteria included patients referred with a diagnosis of anterior uveitis who received a FA in the same visit at the time of presentation. Patients were excluded if they had evidence of posterior segment involvement on clinical exam. The FAs were reviewed to evaluate for the petaloid leakage consistent with cystoid macular edema (CME), optic disc leakage, and the presence of retinal vascular leakage (graded on a scale of none present, mild, and moderate/severe). The primary outcome was the presence of retinal vascular leakage on FA at presentation. Secondary outcomes included the presence of CME and optic disc leakage.

Results : A total of 30 patients (60 eyes) met the inclusion criteria (11 males, 19 females; mean age 52.6, range 26-83 years). FA grading revealed no retinal vascular leakage in 32 eyes (53.3%), mild leakage in 19 eyes (31.7%) and moderate to severe leakage in 9 eyes (15.0%). Further, 14 eyes (23.3%) showed petaloid leakage, and 3 eyes (5%) revealed disc leakage. Retinal vascular leakage was bilateral in 12 cases. FA was helpful in changing the presenting diagnosis in 5 patients (16.7%).

Conclusions : Our preliminary data suggests that anterior uveitis may be associated with retinal vascular changes. In some circumstances it may be helpful to obtain a baseline FA in anterior uveitis patients to ensure that the uveitis is appropriately characterized, especially given the treatment and prognostic implications.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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