Abstract
Purpose :
To evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is
increased in patients with uveitis.
Methods :
In Taiwan’s national health insurance research database, we identified 195,125 patients
with new-onset uveitis between 2001 and 2013. We randomly selected 390,250 individuals
without uveitis who were matched 2:1 to uveitis cases based on age, sex and year of enrolment.
The characteristics of the two groups were compared. Using multivariate Cox regression,
hazard ratios (HRs) for psoriasis or psoriatic arthritis corresponding to uveitis were
computed after adjustment for age, sex, insurance cost and comorbidities. In subgroup analyses,
separate HRs for mild psoriasis, severe psoriasis and psoriatic arthritis were
calculated.
Results :
The mean age of the study cohort was 50.2 ± 17.2 years. Hypertension, diabetes, hyperlipidaemia
and obesity were more prevalent in the uveitis group (all p < 0.0001). The hazard of
psoriasis or psoriatic arthritis development was significantly greater in the uveitis group than
in the non-uveitis group (p < 0.0001); this increased risk persisted after adjustment for confounders
[adjusted HR = 1.41; 95% confidence interval (CI), 1.33–1.48]. Adjusted HRs
showed an increasing trend from mild psoriasis (1.35; 95% CI, 1.28–1.44) to severe psoriasis
(1.59; 95% CI, 1.30–1.94) and psoriatic arthritis (1.97; 95% CI, 1.60–2.42).
Conclusions :
This nationwide population-based cohort study revealed that patients with uveitis have an
increased risk of subsequent psoriasis or psoriatic arthritis development.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.