Abstract
Purpose :
To identify risk factors associated with chalazion and chalazion surgery.
Methods :
Patients with an incident chalazion diagnosis from 2002-2019 were compared 1:5 with matched controls. Multivariate logistic regression identified variables associated with diagnosis and surgical excision, separately.
Results :
Chalazion patients (n=134,959) and controls (6,878,160) were analyzed. Risk factors for diagnosis included female sex, non-white race, Northeast location, conditions affecting periocular skin and tear film (blepharitis, meibomian gland dysfunction, rosacea, pterygium), several non-ocular inflammatory conditions (gastritis, inflammatory bowel disease, sarcoidosis, seborrheic dermatitis, Grave’s disease) and smoking (p<0.001). Diabetes and systemic sclerosis decreased odds of diagnosis (p<0.001). Male sex and rosacea increased odds of surgery (p<0.001). Anxiety, diabetes, gastritis, seborrheic dermatitis, Sjogren’s, and smoking decreased odds of surgery (p<0.001).
Conclusions :
Female sex, non-white race, conditions affecting periocular skin and the tear film, several non-ocular inflammatory conditions, and smoking were risk factors for chalazion diagnosis. Male sex and rosacea were risk factors for surgical intervention for chalazion. Our results prompt further study of these variables and their relationship to chalazion diagnosis to understand physiology and improve clinical outcomes.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.