June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Comparison of long-term efficacy between intravitreal anti-VEGF and photodynamic therapy for the treatment of central serous chorioretinopathy with flat irregular pigment epithelium detachment
Author Affiliations & Notes
  • Jimin Park
    Asan Medical Center, Songpa-gu, Seoul , Korea (the Republic of)
  • Joon Hyung Yeo
    Chung-Ang University, Seoul, Seoul, Korea (the Republic of)
  • Yoon Jeon Kim
    Asan Medical Center, Songpa-gu, Seoul , Korea (the Republic of)
  • Junyeop Lee
    Asan Medical Center, Songpa-gu, Seoul , Korea (the Republic of)
  • Joo Yong Lee
    Asan Medical Center, Songpa-gu, Seoul , Korea (the Republic of)
  • June-Gone Kim
    Asan Medical Center, Songpa-gu, Seoul , Korea (the Republic of)
  • Young Hee Yoon
    Asan Medical Center, Songpa-gu, Seoul , Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Jimin Park None; Joon Hyung Yeo None; Yoon Jeon Kim None; Junyeop Lee None; Joo Yong Lee None; June-Gone Kim None; Young Hee Yoon None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3767 – F0188. doi:
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      Jimin Park, Joon Hyung Yeo, Yoon Jeon Kim, Junyeop Lee, Joo Yong Lee, June-Gone Kim, Young Hee Yoon; Comparison of long-term efficacy between intravitreal anti-VEGF and photodynamic therapy for the treatment of central serous chorioretinopathy with flat irregular pigment epithelium detachment. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3767 – F0188.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the anatomic and functional efficacy of intravitreal anti-vascular endothelial growth factor (VEGF) versus half-dose photodynamic therapy (PDT) treatment in central serous chorioretinopathy (CSC) with flat irregular pigment epithelium detachment (fiPED).

Methods : This retrospective, interventional, comparative study included 72 treatment naive patients with CSC who exhibited fiPED. Among 75 eyes from 72 patients, 42 eyes from 41 patients received anti-VEGF treatment and 33 eyes from 31 patients received half-dose PDT. Treatment outcomes, including the visual acuity, central retinal thickness (CRT), and presence of subretinal fluid (SRF) were evaluated at baseline and 1, 6, 12 and 24 months after treatment and compared between two groups.

Results : There were no differences in baseline characteristics between the two groups. In both groups, a significant improvement of CRT was observed at 1 month after treatment and was maintained throughout the 24-month follow-up period (P < 0.01). Whereas 10 out of 42 eyes (23.8%) with anti-VEGF treatment (mean 6.1 injections/ 2 years) required the alternative treatments (6 with PDT and 4 with focal laser), 1 out of 33 eyes (6.0%) with PDT treatment (mean 1.0 treatment/ 2 years) received focal laser treatment. In addition, PDT group showed significantly higher percentage of SRF resolution than anti-VEGF group (P < 0.05, PDT : 93.75%, anti-VEGF : 45.24% at 12-month follow-up), with lower recurrence rate of SRF (P < 0.05, PDT : 13.8%, anti-VEGF : 68.75% at 24-month follow-up). Likewise, the visual outcome had the similar trend with the anatomic outcomes.

Conclusions : While treatment responses to anti-VEGF and PDT were favorable in CSC with fiPED, PDT treatment showed faster recovery of functional and anatomic outcomes with the lower recurrence, compared with anti-VEGF.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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