June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Spontaneous resolution of subretinal fluid in chronic central serous chorioretinopathy: the Fuji sign
Author Affiliations & Notes
  • Camiel J F Boon
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
    Ophthalmology, Amsterdam UMC Locatie AMC, Amsterdam, North Holland, Netherlands
  • Helena Margaret Anthonia Feenstra
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
  • Jonathan Hensman
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
  • Theodora Gkika
    Ophthalmology, Oxford Eye Hospital, Oxford, Oxfordshire, United Kingdom
  • Carel C B Hoyng
    Ophthalmology, Radboudumc, Nijmegen, Gelderland, Netherlands
  • Roselie M.H. Diederen
    Ophthalmology, Amsterdam UMC Locatie AMC, Amsterdam, North Holland, Netherlands
  • Reinier O. Schlingemann
    Ophthalmology, Amsterdam UMC Locatie AMC, Amsterdam, North Holland, Netherlands
  • Susan M. Downes
    Ophthalmology, Oxford Eye Hospital, Oxford, Oxfordshire, United Kingdom
  • Elon H.C. van Dijk
    Ophthalmology, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, Netherlands
  • Footnotes
    Commercial Relationships   Camiel Boon None; Helena Feenstra None; Jonathan Hensman None; Theodora Gkika None; Carel Hoyng None; Roselie Diederen None; Reinier Schlingemann None; Susan Downes None; Elon van Dijk None
  • Footnotes
    Support  Stichting Blindenhulp; Stichting Macula Fonds; Retina Nederland Onderzoek Fonds; Stichting Blinden-Penning; Algemene Nederlandse Vereniging ter Voorkoming van Blindheid; Landelijke Stichting voor Blinden en Slechtzienden; Oogfonds, which contributed through UitZicht (Delft, the Netherlands); Rotterdamse Stichting Blindenbelangen (Rotterdam, the Netherlands); Stichting Leids Oogheelkundig Ondersteuningsfonds (Leiden, the Netherlands); Stichting Ooglijders (Rotterdam, the Netherlands); the Gisela Thier Fellowship of Leiden University, Leiden, the Netherlands (CB); and the Netherlands Organization for Scientific Research (VENI grant).
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3763 – F0184. doi:
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      Camiel J F Boon, Helena Margaret Anthonia Feenstra, Jonathan Hensman, Theodora Gkika, Carel C B Hoyng, Roselie M.H. Diederen, Reinier O. Schlingemann, Susan M. Downes, Elon H.C. van Dijk; Spontaneous resolution of subretinal fluid in chronic central serous chorioretinopathy: the Fuji sign. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3763 – F0184.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Patients with chronic central serous chorioretinopathy (cCSC) may have spontaneous subretinal fluid (SRF) resolution, but little is known about clinical characteristics that can help to predict which patients will have such a spontaneous resolution. We performed a retrospective clinical study to learn about factors that may predict spontaneous SRF resolution in cCSC patients.

Methods : This retrospective cohort study included 38 treatment-naive cCSC patients in whom spontaneous SRF resolution on optical coherence tomography (OCT) occurred, and 38 gender- and age-matched cCSC patients from the multicenter randomized controlled trials PLACE and SPECTRA, who received treatment after baseline visit. In both groups, clinical characteristics and findings on multimodal imaging were assessed at first presentation. Most importantly, the OCT scan was analyzed for the presence of the Fuji sign, a novel morphological feature on OCT in which SRF has a triangular shape resembling the Japanese Mount Fuji. In addition, the number of focal leakage points on fluorescein angiography (FA) and presence of SRF on OCT in the fellow eye were assessed.

Results : The Fuji sign on OCT occurred significantly more often in the study group compared to the control group (16/38 (42.1%) vs 5/38 (13.2%), respectively; p=0.005). The number of focal leakage points on FA was 0.83 ± 0.72 in the study group and 1.71 ± 1.64 in the control group (p<0.001). SRF on OCT was also present in the fellow eye at baseline visit in 5/38 (13.2%) patients in the study group and in 9/38 (23.7%) patients in the control group.

Conclusions : The Fuji sign on OCT and number of focal leakage points on FA can help to identify which cCSC patients with foveal SRF have a higher chance of spontaneous SRF resolution without treatment.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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