Abstract
Purpose :
To evaluate the association between pachydrusen and changes in fundus autofluorescence (FAF) in eyes with central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV).
Methods :
Retrospective review of 75 eyes with CSC and 33 eyes with PCV. Color fundus photo, FAF and optical coherence tomography (OCT) were evaluated to assess for pachydrusen, changes in FAF and OCT subfoveal choroidal thickness (SFCT).
Results :
Pachydrusen were found in 18.7% of CSC eyes and 63.6% of PCV eyes. The mean age of patients with eyes having pachydrusen was significantly older than those without pachydrusen in both CSC and PCV (P<0.001 and P=0.003, respectively). No significant difference was found in the mean SFCT in both CSC and PCV eyes with or without pachydrusen. More extensive area of FAF abnormalities was found to be associated with eyes with pachydrusen (P=0.041).
Conclusions :
Pachydrusen are more prevalent in eyes with PCV than CSC. Pachydrusen are associated with increasing age and more extensive retinal pigment epithelial abnormalities as shown by the FAF changes.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.