June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Retroprosthetic Membrane Formation Following Glaucoma Procedures with Boston Keratoprosthesis
Author Affiliations & Notes
  • Shawn Gulati
    Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Maria Soledad Cortina
    Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • DEEPAK P EDWARD
    Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Shawn Gulati None; Maria Cortina None; DEEPAK EDWARD Takeda Pharma, Code C (Consultant/Contractor), Genentech, Code S (non-remunerative)
  • Footnotes
    Support  P30 EY001792; Unrestricted grant support from the Research to Prevent Blindness
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3708 – A0393. doi:
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    • Get Citation

      Shawn Gulati, Maria Soledad Cortina, DEEPAK P EDWARD; Retroprosthetic Membrane Formation Following Glaucoma Procedures with Boston Keratoprosthesis. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3708 – A0393.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess features of retroprosthetic membranes (RPM) in Boston Keratoprosthesis (KPro) eyes undergoing diode cyclophotocoagulation (CPC) compared to glaucoma drainage implant (GDI).

Methods : We reviewed records for 193 eyes undergoing KPro surgery from 2007 - 2020. We compared prevalence of RPM, preoperative diagnoses, and visual outcomes following CPC vs. GDI.

Results : 36 eyes met inclusion criteria. 1 eye (3%) had primary CPC, 6 eyes (17%) had both GDI and CPC, and 29 eyes (80%) had GDI without CPC. KPro indication was similar in GDI/CPC group: non-inflammatory (61%, n=22), inflammatory (28%, n=10), and chemical injury (11%, n=4). RPM prevalence was 71% (5/7) in CPC vs. 15% (4/27) in primary GDI (p<0.01) (OR:4.8). Mean time from procedure to RPM formation was 3.9 years and similar between groups. At last visit, in CPC eyes, mean VA was 1.8 logMAR (5/7) and no light perception in others (2/7). In primary GDI eyes, mean VA was 1.2 logMAR (24/27) and ≤ light perception in others (3/27).

Conclusions : RPM occurrence in KPro following CPC was significantly higher than after GDI with poor VA outcome. Our data has implications for glaucoma intervention selection with KPro.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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