June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
A Retrospective Study of Refractive Changes in Diabetic and Non-Diabetic Veterans in an Urban Setting
Author Affiliations & Notes
  • Hector Sandoval
    SUNY Downstate Health Sciences University, New York City, New York, United States
  • Yuan Yang
    Stony Brook University, Stony Brook, New York, United States
  • Wei Hou
    Stony Brook University, Stony Brook, New York, United States
  • Inci Dersu
    SUNY Downstate Health Sciences University, New York City, New York, United States
  • Footnotes
    Commercial Relationships   Hector Sandoval None; Yuan Yang None; Wei Hou None; Inci Dersu None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3601 – A0056. doi:
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      Hector Sandoval, Yuan Yang, Wei Hou, Inci Dersu; A Retrospective Study of Refractive Changes in Diabetic and Non-Diabetic Veterans in an Urban Setting. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3601 – A0056.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Changes in refractive errors are common among diabetics with an increased prevalence of both hyperopia and myopia. However, it is unknown whether refractive errors are associated with changes in eye health or comorbid conditions. The purpose of this retrospective study was to characterize the refractive error changes among diabetic subjects in an urban setting and investigate the relationship between refractive error and eye health or comorbid conditions.

Methods : Medical records from 300 subjects were reviewed over an average time span of 9 years at Brooklyn Veteran’s Affairs Hospital. Subjects were chosen with eye visits in 2021 with a 3-year minimum eye visit history and were excluded if they had previous cataract surgery. Spherical equivalents for baseline and last refractive errors were collected as well as cup-to-disk (C/D) ratios, glaucoma status, body mass index (BMI), and presence of hypertension, hyperlipidemia, coronary artery disease, chronic kidney disease. Chi-square t-test, multiple linear regression, and logistic regression were used for statistical analysis.

Results : Diabetics mean baseline refraction was -0.12 (1.68) right eye (OD) and -0.21 (1.79) left eye (OS) and mean last refraction was 0.13 (1.91) OD and 0.05 (1.88) OS. Non-diabetic subjects mean baseline refraction was -0.16 (2.11) OD and -0.22 (2.22) OS and mean last refraction was 0.08 (2.42) OD and 0.03 (1.12) OS. Refractive error changes among diabetic subjects were 0.25 (0.81) OD and 0.26 (0.88) OS and among non-diabetic subjects 0.24 (1.12) OD and 0.25 (0.86) OS. Using multiple regression, there was a statistically significant negative association between C/D ratio OD and OD refractive change (β = -0.7; p = 0.05) and between BMI and OS refractive change (β = -0.03; p = 0.007). Further analysis showed 1 unit increase in baseline OD/OS refraction was associated with a 0.33 (p = 0.04) and 0.31 (p = 0.07) decrease in BMI respectively. There were no statistically significant associations between refractive error differences and the remaining covariates.

Conclusions : In our study population, a refractive error shift was observed from myopia to hyperopia and refraction error difference was negatively associated with C/D ratio and obesity. No difference was found between refraction error difference among diabetic vs non-diabetic subjects and there was no statistically significantly association with other comorbidities.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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