June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Retinal fractal dimension in prevalent dementia: The AlzEye Study
Author Affiliations & Notes
  • Robert Luben
    University College London, London, London, United Kingdom
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Siegfried Wagner
    University College London, London, London, United Kingdom
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Robbert Struyven
    University College London, London, London, United Kingdom
  • Mario Cortina-Borja
    University College London, London, London, United Kingdom
  • Axel Petzold
    University College London, London, London, United Kingdom
  • Emanuele Trucco
    University of Dundee, Dundee, Dundee, United Kingdom
  • Muthu Rama Krishnan Mookiah
    University of Dundee, Dundee, Dundee, United Kingdom
  • Jugnoo Rahi
    University College London, London, London, United Kingdom
  • Alastair K Denniston
    University of Birmingham, Birmingham, Birmingham, United Kingdom
  • Pearse Andrew Keane
    University College London, London, London, United Kingdom
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Footnotes
    Commercial Relationships   Robert Luben None; Siegfried Wagner None; Robbert Struyven None; Mario Cortina-Borja None; Axel Petzold None; Emanuele Trucco None; Muthu Rama Krishnan Mookiah None; Jugnoo Rahi None; Alastair Denniston None; Pearse Keane Apellis, DeepMind, Code C (Consultant/Contractor), Allergan, Bayer, Heidelberg Engineering, Novartis, Roche, Topcon, Code F (Financial Support), Big Picture Medical, Code I (Personal Financial Interest)
  • Footnotes
    Support  Fight for Sight Small Grant Award: 24AZ171
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4440 – F0119. doi:
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      Robert Luben, Siegfried Wagner, Robbert Struyven, Mario Cortina-Borja, Axel Petzold, Emanuele Trucco, Muthu Rama Krishnan Mookiah, Jugnoo Rahi, Alastair K Denniston, Pearse Andrew Keane; Retinal fractal dimension in prevalent dementia: The AlzEye Study. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4440 – F0119.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyse the association between retinal fractal dimension (FD) and all-cause dementia in a large ethnically and socioeconomically diverse cohort in London, United Kingdom.

Methods : The AlzEye project is a retrospective cohort study linking ophthalmic imaging of all patients attending Moorfields Eye Hospital aged ≥ 40 years with secondary care Hospital Episodes Statistics Admissions data between January 1st 2008 and March 31st 2018. Dementia diagnoses were coded using the International Classification of Diseases, 10th revision. Retinal fractal dimension was extracted from macular-centered colour fundus photographs using the Vascular Assessment and Measurement Platform for Images of the Retina. Multivariable linear regression was used to examine the association between retinal FD and dementia.

Results : Among 96,995 patients, 4353 had a diagnosis of dementia: 1222 with AD, 885 with VD, 229 with mixed disease and 2017 with unspecified dementia . Compared to those without dementia, patients with dementia were older (79.7 +/- 8.6 vs 67.7+/-12.4), more likely to be women (58.7% vs 50.6%) and more likely to have hypertension (83.3% vs 80.4%, all p<0.001). Patients with dementia had reduced retinal FD after adjusting for age, sex, diabetes mellitus and hypertension (beta: -0.0047; 95% CI: -0.005, -0.003; p<0.001). No interaction was apparent among covariates.

Conclusions : A strong inverse association was seen between retinal FD and prevalent all-cause dementia after adjustment of known confounders of FD. Subsequent analyses will examine associations between other metrics of retinal morphology, derived from optical coherence tomography and incident disease.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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