June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Short-term changes in Bruch’s Membrane Opening-Based Morphometrics during the first week after trabeculectomy
Author Affiliations & Notes
  • Philip Enders
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
    Glaucoma Imaging Center University of Cologne, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Jan Lüke
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Thomas S Dietlein
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Alexandra Lappas
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Verena Prokosch
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Sigrid Roters
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Ludwig M Heindl
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Claus Cursiefen
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Caroline Gietzelt
    Department of Ophthalmology, Universitat zu Koln, Koeln, Nordrhein-Westfalen, Germany
  • Footnotes
    Commercial Relationships   Philip Enders None; Jan Lüke None; Thomas Dietlein None; Alexandra Lappas None; Verena Prokosch None; Sigrid Roters None; Ludwig Heindl None; Claus Cursiefen None; Caroline Gietzelt None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4258. doi:
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      Philip Enders, Jan Lüke, Thomas S Dietlein, Alexandra Lappas, Verena Prokosch, Sigrid Roters, Ludwig M Heindl, Claus Cursiefen, Caroline Gietzelt; Short-term changes in Bruch’s Membrane Opening-Based Morphometrics during the first week after trabeculectomy. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4258.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the dynamics of Bruch’s membrane opening-based morphometrics of the optic nerve head (ONH) using spectral domain optical coherence tomography (SD-OCT) during the first week after glaucoma surgery by trabeculectomy with mitomycin C.

Methods : Prospective, longitudinal analysis of 25 eyes of 25 patients treated by trabeculectomy. Twenty-four eyes had evaluable postoperative SD-OCT examinations. Bruch’s membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness were analyzed at baseline before surgery, one day, two to three days and one week after surgery. Changes compared to baseline were correlated to intraocular pressure (IOP).

Results : One day after surgery, BMO-MRW changed on average by +24.0%, p=0.002 (IOP reduction by 5.4±13.9 mmHg). This increase persisted on day 2-3 with a mean increase of BMO-MRW of +19.8%, p<0.001 (IOP reduction by 9.2±14.7 mmHg) and by week 1 with a mean BMO-MRW increase of+25.3%, p=0.002 (IOP reduction by 9.9±16.1mmHg). The increase in BMO-MRW correlated significantly with the reduction of IOP on day 1 (Spearman’s rho ρ=0.656, p=0.003) and d2-3 (Spearman’s rho ρ=0.479, p=0.038). There was no statistically significant correlation found between the IOP and the increase in BMO-MRW in week 1. RNFL thickness showed no significant changes at all three follow up intervals (p≥0.096 respectively).

Conclusions : Structural reversal of disc cupping in BMO-MRW occurs as early as one day after trabeculectomy and correlates to the extent of the IOP reduction. During the whole first week after surgery a strong increase in BMO-MRW can be noted. The changes in BMO-based parameters need to be considered when evaluating patients’ longitudinal follow-up.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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