June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Long-Term Follow-Up of Biomechanical Changes in Very Asymmetric Ectasia
Author Affiliations & Notes
  • Shizuka Koh
    Innovative Visual Science, Osaka Daigaku, Suita, Osaka, Japan
    Ophthalmology, Osaka Daigaku, Suita, Osaka, Japan
  • Ryota Inoue
    Innovative Visual Science, Osaka Daigaku, Suita, Osaka, Japan
    SEED CO., LTD., Tokyo, Japan
  • Sayo Maeno
    Ophthalmology, Osaka Daigaku, Suita, Osaka, Japan
  • Naoyuki Maeda
    Ophthalmology, Osaka Daigaku, Suita, Osaka, Japan
  • Renato Ambrósio
    Ophthalmology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Instituto de Olhos Renato Ambrósio/Visare Personal Laser, Rio de Janeiro, Brazil
  • Vishal Jhanji
    Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Kohji Nishida
    Ophthalmology, Osaka Daigaku, Suita, Osaka, Japan
  • Footnotes
    Commercial Relationships   Shizuka Koh SEED, Rohto, Code F (Financial Support), Alcon, Cooper Vision, JCR, J&J, Menicon, Novartis, Oculus, Ophtecs Otsuka, Rohto, Sanofi, Santen, SEED, Senju, Sumitomo Dainippon Pharma  , Code R (Recipient); Ryota Inoue SEED, Code E (Employment); Sayo Maeno None; Naoyuki Maeda Oculus, Code R (Recipient); Renato Ambrósio Oculus, Code C (Consultant/Contractor); Vishal Jhanji None; Kohji Nishida None
  • Footnotes
    Support  This work was supported by SEED CO., LTD.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4253. doi:
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      Shizuka Koh, Ryota Inoue, Sayo Maeno, Naoyuki Maeda, Renato Ambrósio, Vishal Jhanji, Kohji Nishida; Long-Term Follow-Up of Biomechanical Changes in Very Asymmetric Ectasia. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4253.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To investigate chronological corneal biomechanical changes in fellow eyes with normal topography from patients with very asymmetric ectasia (VAE) for 3 years.

Methods : The clinical records of patients with VAE were retrospectively reviewed. Patients with VAE were defined as having clinical ectasia in one eye and a fellow eye with normal topography. Corneal biomechanical assessment with high-speed dynamic Scheimpflug-based corneal imaging was performed at baseline and at each follow-up visit in each eye. The deformation amplitude ratio within 2 mm, integrated radius, Ambrósio relational thickness to the horizontal profile, stiffness parameter at the first applanation (SPA1), Corvis Biomechanical Index (CBI), stress–strain index (SSI), and tomographic/biomechanical index were used to investigate the chronological changes in biomechanical parameters. Linear mixed-effects models were used to evaluate changes in biomechanical and clinical parameters over time.

Results : Thirty patients (17 men, 13 women) with VAE met the study criteria. The patients’ age at baseline examination was 46.4 ± 14.4 years. Significant changes in SPA1, CBI, and SSI (p = 0.048, p = 0.012, and p=0.011, respectively) were observed during the 3-year period, and only SSI showed a decreasing trend over time. There were no significant changes in other corneal biomechanical parameters and clinical parameters during the 3-year period. A significant association between the SSI and age at initial biomechanical assessment. (p<0.001)

Conclusions : Based on corneal biomechanical evaluation over a 3-year period, possible corneal softening in such eyes was observed, highlighting the characteristics of progressive ectatic corneal disorder even in a subclinical status. Future studies using a longer follow-up period are required.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.


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