June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Light-Adapted Electroretinographic (ERG) Responses to Full-Field Stimuli in Children Treated for Retinopathy of Prematurity (ROP)
Author Affiliations & Notes
  • Amber-Lee Curran
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
  • Deborah Vanderveen
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
    Harvard Medical School, Boston, Massachusetts, United States
  • Iason Mantagos
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
    Harvard Medical School, Boston, Massachusetts, United States
  • Carolyn Wu
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
    Harvard Medical School, Boston, Massachusetts, United States
  • James D Akula
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
    Northeastern University, Boston, Massachusetts, United States
  • Anne B Fulton
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
    Harvard Medical School, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Amber-Lee Curran None; Deborah Vanderveen None; Iason Mantagos None; Carolyn Wu None; James Akula None; Anne Fulton None
  • Footnotes
    Support  NH Grant EY10597-23
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4185 – F0245. doi:
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    • Get Citation

      Amber-Lee Curran, Deborah Vanderveen, Iason Mantagos, Carolyn Wu, James D Akula, Anne B Fulton; Light-Adapted Electroretinographic (ERG) Responses to Full-Field Stimuli in Children Treated for Retinopathy of Prematurity (ROP). Invest. Ophthalmol. Vis. Sci. 2022;63(7):4185 – F0245.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare cone-mediated ERG responses to full-field stimuli in children with severe ROP treated with either intravitreal bevacizumab (IVB) or laser photocoagulation.

Methods : Light-adapted responses to a range of red flash intensities were recorded. Cone photoreceptor sensitivity and saturated amplitude were calculated from the a-wave. Post-receptor activity (represented by the b-wave) and inner retinal function (represented by the oscillatory potentials (OPs)) were also analyzed. All response parameters were expressed relative to the mean of the IVB group. Linear mixed effects (LME) modeling was used to determine significant differences between groups. We studied children treated with IVB (n=20; 37 eyes) or laser (n=10; 17 eyes). Twelve patients (22 eyes) receiving IVB required additional laser treatment. Among these groups there was little difference in gestational age, birthweight, or age at ERG test. The gestational age at birth was median 25 (range 21–31) weeks and birthweight was median 572.5 (range 410–1750) g. Corrected age at ERG was median 47.4 (range 8–1,334) weeks. None had retinal detachment.

Results : The first LME model detected a significant difference in function at the various retinal depths (P < 0.05). Inner retinal function, represented by the OPs, was higher in laser-treated eyes. Photoreceptor and post-receptor function were similar across the groups. The second LME model detected no significant difference between IVB patients who required subsequent laser and those who did not.

Conclusions : These cone-mediated ERG data identify significant difference between IVB and laser-treated ROP retinas. Specifically, laser may confer relative preservation of the inner retina.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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