June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Relationship of Multifocal Electroretinographic Responses and Macular Layer Volume in Eyes Treated for Retinopathy of Prematurity
Author Affiliations & Notes
  • Bilal K AlWattar
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
    Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
  • Jagvi K Patel
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
  • Mariana I Fonseca
    Northeastern University, Boston, Massachusetts, United States
  • Alexandra Nouck-a-Nwal
    Northeastern University, Boston, Massachusetts, United States
  • Pablo Altschwager
    Pontificia Universidad Catolica de Chile Facultad de Medicina, Santiago, Chile
  • Anne B Fulton
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
    Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
  • James D Akula
    Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, United States
    Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Bilal AlWattar None; Jagvi Patel None; Mariana Fonseca None; Alexandra Nouck-a-Nwal None; Pablo Altschwager None; Anne Fulton None; James Akula None
  • Footnotes
    Support  NIH EY028953
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4180 – F0240. doi:
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      Bilal K AlWattar, Jagvi K Patel, Mariana I Fonseca, Alexandra Nouck-a-Nwal, Pablo Altschwager, Anne B Fulton, James D Akula; Relationship of Multifocal Electroretinographic Responses and Macular Layer Volume in Eyes Treated for Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4180 – F0240.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : There is marked attenuation in the amplitudes of N1 and P1 in the mfERG responses of eyes with a history of severe (i.e., treated) ROP; N1 and P1 in eyes with a history of mild (i.e., untreated) or no ROP differ little from term-born controls (Altschwager et al., 2017). We aimed to determine the cellular origins of these previously reported deficits.

Methods : We measured the moment-by-moment association of response amplitude and the volume of retinal layers in the respective retinal regions stimulated by the standard 103 scaled hexagonal mfERG elements. Adolescent and adult subjects (N=45) participated. Each element was aligned to its corresponding area on the OCT; stimuli falling on the fovea and on the optic nerve head were excluded. The OCT volumes were segmented into “photoreceptor,” “postreceptor,” and “inner” retinal layers. Linear mixed-effects modeling was used to derive estimated coefficients (voltage/volume) for each layer throughout the full 80-ms standard epoch in subjects with (a) no history of ROP (N=26), (b) a history of ROP too mild to require treatment (N=15), and (c) severe ROP treated with laser photoablation (N=4).

Results : Overall, volume of the photoreceptor layer was attenuated while the inner layer was enlarged in the severe retinae. The modeling revealed no marked differences in the mfERG-to-OCT relationships among subjects with no history of ROP or a history of mild ROP. However, it suggested that the marked attenuation in the amplitudes of N1 and P1 in the mfERG responses of severe ROP subjects results mostly from a combination of decreased cornea-negative postreceptor potentials and a latency shift in cornea-positive postreceptor potentials that flatten P1 (but do not much change its implicit time). Also, because the contribution of the inner retina was most significant in the interval between the prominent troughs/peaks of the intact response, it did not rescue N1 and P1 amplitudes. Across all groups, photoreceptor retinal responses differed little.

Conclusions : Model results were in good overall agreement with previous interpretations of the origins of the mfERG. The marked mfERG abnormalities in eyes with severe ROP are probably mediated in large part by changes in bipolar cell function. There was no evidence of dysfunction in the macular cones.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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