June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Differences in the relationship between intraocular pressure and optic nerve head oxygenation in open angle glaucoma patients of African and European Descent
Alice Chandra Verticchio Vercellin; Alon Harris; James Beach; Richard B Rosen; George Eckert; Oscar Otero; Julia Arciero; Louis Pasquale; Brent A Siesky
Author Affiliations & Notes
  • Alice Chandra Verticchio Vercellin
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alon Harris
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • James Beach
    University of Minnesota Center for Drug Design, Minneapolis, Minnesota, United States
  • Richard B Rosen
    New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • George Eckert
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Oscar Otero
    New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Julia Arciero
    Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States
  • Louis Pasquale
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Brent A Siesky
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Alice Chandra Verticchio Vercellin None; Alon Harris AdOM, Qlaris, Luseed, Cipla, Code C (Consultant/Contractor), AdOM, Luseed, Oxymap, Qlaris, Phileas Pharma, SlitLed, QuLent, Code I (Personal Financial Interest), AdOM, Qlaris, Phileas Pharma, Code S (non-remunerative); James Beach None; Richard Rosen OptoVue, Code C (Consultant/Contractor), Boehringer-Ingelheim, Code C (Consultant/Contractor), OptoVue, Code F (Financial Support), Ocusciences, Code F (Financial Support), Topcon, Code F (Financial Support), Opticology, Code I (Personal Financial Interest), Guardion, Code I (Personal Financial Interest), OptoVue, Code P (Patent); George Eckert None; Oscar Otero None; Julia Arciero None; Louis Pasquale Eyenovia, Twenty Twenty, and Skye Bioscience, Code C (Consultant/Contractor); Brent Siesky None
  • Footnotes
    Support  NIH grant (R01EY030851), NYEE Foundation grant, and in part by a Challenge Grant award from Research to Prevent Blindness, NY.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4023 – A0408. doi:
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      Alice Chandra Verticchio Vercellin, Alon Harris, James Beach, Richard B Rosen, George Eckert, Oscar Otero, Julia Arciero, Louis Pasquale, Brent A Siesky; Differences in the relationship between intraocular pressure and optic nerve head oxygenation in open angle glaucoma patients of African and European Descent. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4023 – A0408.

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Abstract

Purpose : To examine the relationship between intraocular pressure (IOP) and retinal oxygen saturation in open angle glaucoma (OAG) patients of African (AD) and European descent (ED).

Methods : 31 patients with OAG (13 AD, 18 ED) were assessed in a cross-sectional analysis for IOP via Goldmann applanation tonometry and retinal oxygenation via retinal photographic oximetry (Oxymap Retinal Oximeter; Oxymap ehf, Reykjavik, Iceland). Age-adjusted two-sample t-tests and Spearman correlations were used to test for differences and associations between measurements, with p<0.05 considered statistically significant.

Results : OAG patients of AD and ED demonstrated significantly different relationships between IOP and retinal venous oxygen biomarkers, despite statistically similar IOP (p=0.418) and visual field outcomes (mean deviation, pattern standard deviation, and visual field index, all p>0.05). Strong negative correlations were found between IOP and oxygenation biomarkers in OAG patients of ED, while these correlations were weaker and/or positive in AD patients (p=0.008-0.038; e.g., IOP vs. oxygen saturation (SatO2) in the inferior nasal vein ED r=-0.99, AD r=-0.19, p=0.008). IOP was also strongly and positively correlated with the infero-nasal arterio-venous difference in OAG patients of ED, while the correlation was weak and negative in AD patients (ED r=0.97, AD r=-0.13, p=0.021). Although OAG patients of AD had higher ocular perfusion pressures (OPP), compared to those of ED (p=0.021); OPP was not found to be significantly different in its relationships with ONH oxygen biomarkers (p<0.05) between groups.

Conclusions : In this cohort of patients, the relationship between IOP and retinal oxygen saturation were significantly different between OAG patients of AD and ED. Our results suggest that despite statistically similar IOP, the impact of IOP on retinal metabolism may be different in persons of AD, especially within the venous circulation.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2024 Association for Research in Vision and Ophthalmology.
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