June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
tRNS and exercise do not modulate ocular dominance plasticity
Author Affiliations & Notes
  • Xiaoxin Chen
    Human Visual Neuroscience Laboratory, School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, Canada
  • Kennedy Hall
    Translational Vision Science Lab, Chicago College of Optometry, Midwestern University - Downers Grove Campus, Downers Grove, Illinois, United States
  • Amy Nguyen
    Translational Vision Science Lab, Chicago College of Optometry, Midwestern University - Downers Grove Campus, Downers Grove, Illinois, United States
  • Grant Sealock
    Translational Vision Science Lab, Chicago College of Optometry, Midwestern University - Downers Grove Campus, Downers Grove, Illinois, United States
  • Tiffany Tran
    Translational Vision Science Lab, Chicago College of Optometry, Midwestern University - Downers Grove Campus, Downers Grove, Illinois, United States
  • Nicholas Vo
    Translational Vision Science Lab, Chicago College of Optometry, Midwestern University - Downers Grove Campus, Downers Grove, Illinois, United States
  • Benjamin Thompson
    Human Visual Neuroscience Laboratory, School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, Canada
    Centre for Eye and Vision Research Limited, Hong Kong, Hong Kong
  • Arijit Chakraborty
    Translational Vision Science Lab, Chicago College of Optometry, Midwestern University - Downers Grove Campus, Downers Grove, Illinois, United States
    Human Visual Neuroscience Laboratory, School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, Canada
  • Footnotes
    Commercial Relationships   Xiaoxin Chen None; Kennedy Hall None; Amy Nguyen None; Grant Sealock None; Tiffany Tran None; Nicholas Vo None; Benjamin Thompson None; Arijit Chakraborty None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2547 – F0501. doi:
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      Xiaoxin Chen, Kennedy Hall, Amy Nguyen, Grant Sealock, Tiffany Tran, Nicholas Vo, Benjamin Thompson, Arijit Chakraborty; tRNS and exercise do not modulate ocular dominance plasticity. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2547 – F0501.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A period of monocular patching (MD) briefly increases the contribution of the previously patched eye to binocular vision. The magnitude of this effect, known as ocular dominance plasticity, provides an index of short-term visual cortex neuroplasticity.
We used ocular dominance plasticity to assess whether physical exercise and/or visual cortex transcranial random noise stimulation (tRNS), a form of non-invasive brain stimulation, enhance short-term visual cortex neuroplasticity in adults with normal vision.

Methods : Participants (n = 10, mean age = 25 ± 2) completed four daily sessions involving two hours of dominant eye patching while watching a movie. Exercise (cycling) and visual cortex tRNS were applied during patching according to the following conditions: 1) cycling and tRNS, 2) cycling and sham (placebo) tRNS, 3) tRNS sitting still, 4) sham tRNS sitting still. Cycling was completed in six 10-minute blocks interleaved with 10-minute rest periods. High-frequency tRNS (100-640 Hz, 1mA) was delivered during the final 20 minutes of patching. Eye dominance was measured using a computerized dichoptic letter luminance judgement test (Bossi et al., 2018) before and after patching.

Results : As expected, MD increased patched eye dominance in most participants. Two-way repeated measures ANOVA revealed that the magnitude of ocular dominance plasticity was not affected by exercise, visual cortex tRNS or their combination.

Conclusions : Physical exercise and tRNS, individually or in combination, do not enhance short-term ocular dominance plasticity in adults with normal vision.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Illustration of procedures in this experiment. The eye dominance test stimuli were presented dichoptically.

Illustration of procedures in this experiment. The eye dominance test stimuli were presented dichoptically.

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