Investigative Ophthalmology & Visual Science Cover Image for Volume 63, Issue 7
June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Scotoma Replacement: simulation of vision with photoreceptor scotoma
Author Affiliations & Notes
  • Eli Peli
    Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Robert Goldstein
    Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Jae-Hyun Jung
    Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Eli Peli None; Robert Goldstein None; Jae-Hyun Jung None
  • Footnotes
    Support  NIH Grant EY023385
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2464 – F0041. doi:
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    • Get Citation

      Eli Peli, Robert Goldstein, Jae-Hyun Jung; Scotoma Replacement: simulation of vision with photoreceptor scotoma. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2464 – F0041.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Most simulations of vision with scotomas are wrongly represented as black patches over the image. While paracentral scotomas are not explicitly observable by patients, central scotomas due to photoreceptor damage are reported as “blurred” vision. Pyramidal models representing the multiscale contrast processing of the visual system have been used to simulate vision with field loss. However, these simulations blended the low frequency image content, without completely removing it. Here, we present a physiologically plausible computation scheme for scene appearance with photoreceptor scotomas.

Methods : After the pixel values in scotomatous areas in an image are replaced with “not a number” (NaN), we apply a pyramidal model (Peli, JOSA 1991, 2001) in the spatial domain. The interaction of the NaN with the pyramidal structure results in a simulated image that replaces the scotoma.

Results : Content from outside the scotomatous area is drawn into the scotoma by the response of cells higher in the visual pathway centered within the scotoma but with wide receptive fields extending outside the scotoma. The resulting simulation with no black patch is consistent with patients’ descriptions (Figs 1 & 2). Due to the high spatial correlation typical of natural images, the replacement image is highly consistent with the elided part of the scene. The areas outside the scotomatous area are seen by the residual functioning normal peripheral low-resolution retina. The result is a filling-in like effect without any cortical processing or adaptation.

Conclusions : The simulations provide insight into the lack of visibility of scotomas and further point to possible distinctions between field loss due to photoreceptor loss and higher cells loss (Peli, ARVO 2020).

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Simulated view with 8° central photoreceptor scotoma. The elided content is replaced with replications of the surrounding content, within wider rings farther centrally in the scotoma. The lower resolution outside the scotoma is the effect of the retinal eccentricity.

Simulated view with 8° central photoreceptor scotoma. The elided content is replaced with replications of the surrounding content, within wider rings farther centrally in the scotoma. The lower resolution outside the scotoma is the effect of the retinal eccentricity.

 

Simulated view with 30° diameter ring photoreceptor scotoma, as in retinitis pigmentosa. Fixation is to the right edge. Inside the ring resolution is mildly reduced but outside the ring resolution is very poor. Within the ring, the elided content is replaced with “filtered” repeated/periodic versions of the external content from just inside and outside of the ring scotoma.

Simulated view with 30° diameter ring photoreceptor scotoma, as in retinitis pigmentosa. Fixation is to the right edge. Inside the ring resolution is mildly reduced but outside the ring resolution is very poor. Within the ring, the elided content is replaced with “filtered” repeated/periodic versions of the external content from just inside and outside of the ring scotoma.

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