June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Spectral-domain optical coherence tomography morphological characteristics in patients with cone dystrophy
Author Affiliations & Notes
  • Hassan khojasteh
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • Fatemeh Bazvand
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • mostafa haidari
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • Alireza Mahmoudi
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • S.Saeed Mohammadi
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • Hamid Riazi Esfahani
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • Masoud Mirghorbani
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • Afsaneh Azarkish
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • Jonathan Regenold
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
  • Amir Akhavanrezayat
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
  • Irmak Karaca
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
  • SungWho Park
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
  • Gunay Uludag
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
  • Chi Mong Or
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
  • Hashem Ghoraba
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
  • Quan Dong Nguyen
    Byer Eye Institute,Stanford University School of Medicine, Palo Alto, California, United States
  • Footnotes
    Commercial Relationships   Hassan khojasteh None; Fatemeh Bazvand None; mostafa haidari None; Alireza Mahmoudi None; S.Saeed Mohammadi None; Hamid Riazi Esfahani None; Masoud Mirghorbani None; Afsaneh Azarkish None; Jonathan Regenold None; Amir Akhavanrezayat None; Irmak Karaca None; SungWho Park None; Gunay Uludag None; Chi Mong Or None; Hashem Ghoraba None; Quan Nguyen None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4075 – F0039. doi:
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      Hassan khojasteh, Fatemeh Bazvand, mostafa haidari, Alireza Mahmoudi, S.Saeed Mohammadi, Hamid Riazi Esfahani, Masoud Mirghorbani, Afsaneh Azarkish, Jonathan Regenold, Amir Akhavanrezayat, Irmak Karaca, SungWho Park, Gunay Uludag, Chi Mong Or, Hashem Ghoraba, Quan Dong Nguyen; Spectral-domain optical coherence tomography morphological characteristics in patients with cone dystrophy. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4075 – F0039.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe spectral-domain optical coherence tomography (SD-OCT) morphological features of patients with cone dystrophy and to determine the relationship between these findings and visual acuity.

Methods : Forty-two patients (84 eyes) with the diagnosis of cone dystrophy based on clinical findings and electroretinogram (severely reduced or non-recordable cone response with preserved rod function) were included in our study. SD-OCT imaging was performed and images were evaluated regarding the integrity and pattern of hyper-reflective outer retinal bands and other findings. The relationship between these findings, age, central retinal thickness (CRT), and best-corrected visual acuity (BCVA) was assessed.

Results : SD-OCT images of 82 eyes showed outer retinal abnormalities. Five SD-OCT morphological categories were found (figure 1): Outer retinal atrophy (24.4%), undifferentiated outer retinal layers (22.0%), ellipsoid zone (EZ) disruption (19.5%), outer foveal defect (17.1%), and prominent outer retinal layers (17.1%). Also, five isolated OCT findings were found (figure 2) including, foveal hypoplasia (14.6%), trans-retinal hyperreflective dots (THD) (29.3%), outer plexiform layer (OPL) schisis (11.3%), pseudodrusen (9.8%), and EZ bowing (13.4%). Age and CRT were significantly different across the morphological categories (p<0.001). Eyes with prominent outer retinal layers and outer retinal atrophy had the best and worst visual acuity, respectively.

Conclusions : SD-OCT imaging shows extensive morphologic findings in cone dystrophy, which can be utilized to evaluate/diagnose these patients and may serve as predictive biomarkers of visual acuity.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

 

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