Abstract
Purpose :
We compared the macular choriocapillaris flow deficit density (FDD) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA) in healthy participants (normal controls; n=104), individuals having ocular hypertension (OHT; n=41), and primary open-angle glaucoma (POAG; n=112).
Methods :
In this prospective cross-sectional study, subjects underwent 3x3 mm2 imaging using both SS-OCTA (Plex Elite 9000) and SD-OCTA (Cirrus AngioPlex). Choriocapillaris OCTA images were extracted from the respective devices’ built-in review software and were subsequently loaded into a customized algorithm that evaluted the choriocapillaris FDD.
Results :
When using SS-OCTA, older age was independently associated with higher choriocapillaris FDD (all P ≤ 0.026), after adjusting for confounders. Specifically, the oldest group (70-82 years old) had 1.11% (95% CI = 0.50 to 1.72; P < 0.001) more choriocapillaris FDD compared to the youngest group (24-44 years old). In addition, OHT patients had 0.86% (95% CI = 0.10 to 1.62; P = 0.026) more choriocapillaris FDD than normal controls, while it did not reach statistical significance for POAG (β = -0.78, 95% CI = -1.65 to 0.062; P = 0.08). In eyes imaged with SD-OCTA, choriocapillaris FDD was not associated with either age or eye disease.
Conclusions :
Imaging with SS-OCTA showed higher choriocapillaris FDD in older patients and patients with OHT when compared with normal subjects, and this was not seen when imaged with SD-OCTA.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.