June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Association between retinal vein occlusion and Life’s Simple 7 cardiovascular health metrics: a large claims database study
Author Affiliations & Notes
  • Yohei Hashimoto
    Ophthalmology, Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan
    Department of Clinical Epidemiology & Health Economics, School of Public Health, Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan
  • Hidehiro Kaneko
    Department of Cardiovascular Medicine, Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan
  • Akira Okada
    Department of Prevention of Diabetes and Lifestyle-Related Diseases, Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan
  • Hiroki Matsui
    Department of Clinical Epidemiology & Health Economics, School of Public Health, Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan
  • Hideo Yasunaga
    Department of Clinical Epidemiology & Health Economics, School of Public Health, Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan
  • Makoto Aihara
    Ophthalmology, Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan
  • Ryo Obata
    Ophthalmology, Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Yohei Hashimoto None; Hidehiro Kaneko None; Akira Okada None; Hiroki Matsui None; Hideo Yasunaga None; Makoto Aihara None; Ryo Obata None
  • Footnotes
    Support  The Ministry of Health, Labour and Welfare, Japan (21AA2007); The Ministry of Education, Culture, Sports, Science and Technology, Japan (20H03907 and 21H03159).
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2529 – A0098. doi:
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    • Get Citation

      Yohei Hashimoto, Hidehiro Kaneko, Akira Okada, Hiroki Matsui, Hideo Yasunaga, Makoto Aihara, Ryo Obata; Association between retinal vein occlusion and Life’s Simple 7 cardiovascular health metrics: a large claims database study. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2529 – A0098.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Cardiovascular diseases and retinal vein occlusion (RVO) share many risk factors in common. We aimed to clarify the association between RVO occurrence and cardiovascular health (CVH) metrics called the Life’s Simple 7 advocated by the American Heart Association.

Methods : Design: Retrospective cohort study.
Subjects: Individuals undergoing health checkups from 2005 to 2020 in the JMDC Claims Database (JMDC Inc., Tokyo, Japan).
Methods: We set the two exposures: 1) each component of the CVH metrics: body mass index, blood pressure (BP), fasting blood glucose, total cholesterol, smoking, dietary habits, and physical activity; and 2) the number of non-ideal CVH metrics (non-ideal CVH score, ranging from 0 [healthiest] to 7 [unhealthiest]). The outcome was RVO occurrence, identified by the first date of the diagnosis. We performed Cox regression in which RVO occurrence was regressed on the above exposures, age, and sex.
Main Outcome Measures: Hazard ratios for RVO occurrence of 1) each component of the CVH metrics and 2) the non-ideal CVH score.

Results : A total of 2,093,536 individuals were eligible. During a mean follow-up of 1,070 ± 884 days, 3,265 RVO events occurred. Non-ideal BP was most strongly associated with increased risk of RVO occurrence (hazard ratio [HR], 2.25 [95% confidence interval, 2.06–2.46]), followed by non-ideal BMI (HR, 1.30 [1.20–1.40]). Higher non-ideal CVH scores were associated with increased risk of RVO occurrence: adjusted HRs of the groups with non-ideal CVH scores of 6–7, 5 ,4, 3, 2, and 1 were 3.68 (2.61–5.20), 2.83 (2.03–3.95), 2.54 (1.83–3.53), 2.21 (1.59–3.06), 1.78 (1.28–2.47), and 1.39 (0.98–1.95), respectively, compared to the healthiest group with the score 0. This trend was also observed in the subgroups with and without ideal BP.

Conclusions : The strongest risk factor for RVO was non-ideal BP, followed by non-ideal BMI. Non-ideal CVH score, an indicator of unhealthy lifestyle, was dose-dependently associated with RVO occurrence, which also applied to the individuals with ideal-BP. Public health and individual efforts to manage these modifiable risk factors are essential for preventing RVO.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Association between each cardiovascular health metrics and RVO occurrence.
RVO = retinal vein occlusion.

Association between each cardiovascular health metrics and RVO occurrence.
RVO = retinal vein occlusion.

 

Association between the non-ideal CVH scores and RVO occurrence.
RVO, retinal vein occlusion; CVH, cardiovascular health.

Association between the non-ideal CVH scores and RVO occurrence.
RVO, retinal vein occlusion; CVH, cardiovascular health.

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