June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Inter-Eye Comparison of Lamina Cribrosa Depth between Eyes with Asymmetrical Severity in Bilateral Normal-Tension Glaucoma Patients
Author Affiliations & Notes
  • Jae Yeon Lee
    ophthalmology, Kangwon National University Hospital, Chuncheon, Kangwon, Korea (the Republic of)
  • Payam Hosseinzadeh Kasani
    bigdata convergence, Kangwon National University, Chuncheon, Gangwon-do, Korea (the Republic of)
  • Sungok Kwon
    bigdata convergence, Kangwon National University, Chuncheon, Gangwon-do, Korea (the Republic of)
  • Jeong-Ah Kim
    ophthalmology, Kangwon National University Hospital, Chuncheon, Kangwon, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Jae Yeon Lee None; Payam Kasani None; Sungok Kwon None; Jeong-Ah Kim None
  • Footnotes
    Support  HI19C0481, HC19C0276
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2419 – A0353. doi:
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      Jae Yeon Lee, Payam Hosseinzadeh Kasani, Sungok Kwon, Jeong-Ah Kim; Inter-Eye Comparison of Lamina Cribrosa Depth between Eyes with Asymmetrical Severity in Bilateral Normal-Tension Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2419 – A0353.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the association between lamina cribrosa depth (LCD) and severity of glaucomatous damage in bilateral Normal-Tension Glaucoma (NTG) patients who have more damage in one eye.

Methods : Optic nerve heads (ONH) were scanned using enhanced-depth spectral-domain optical coherence tomography. LCD was measured at the three locations spaced equidistantly across the vertical optic disc diameter using ONH horizontal B-scan images. LCDs were compared between more damaged and contralateral eyes. The association between LCD and the severity of glaucomatous damage was analyzed by using logistic regression analysis. Additionally, the conditional logistic regression analysis was performed to identify the ocular risk factors associated with more damage between both eyes in the individuals.

Results : A total of 72 eyes of 36 bilateral NTG patients were included. The mean age of patients was 66.8 ± 13.0 years, and 21 patients (58.3%) were male. More damaged eyes had thinner global retinal nerve fiber layer thickness (P < 0.001), worse visual field mean deviation (P = 0.032), and pattern standard deviation than contralateral eyes (P < 0.001). In contrast, there were no significant inter-eye differences in intraocular pressure, spherical equivalent, and axial length. Average LCD was significantly larger in more damaged eyes (514.2 ± 129.3 vs. 481.9 ± 114.2 μm, P = 0.006). While the severity of the glaucomatous damage was not correlated with the degree of LCD in more and less damaged eyes, the eye with deeper LCD had a higher risk for having severe damage between both eyes with similar systemic condition (odds ratio, 1.017; 95% confidence interval, 1.003-1.301; P = 0.021).

Conclusions : Average LCD was significantly larger in eyes with more damage, suggesting that LC deformation would be associated with glaucomatous ONH damage in the NTG eye.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Inter-eye comparison of LCD in three horizontal ONH B-scan images between eyes with asymmetrical severity in bilateral NTG patients. Note that the LCDs were deeper at all three planes in eyes with more damage than contralateral eyes (all Ps < 0.05). LCD = lamina cribrosa depth; ONH = optic nerve head; NTG = normal tension glaucoma.

Inter-eye comparison of LCD in three horizontal ONH B-scan images between eyes with asymmetrical severity in bilateral NTG patients. Note that the LCDs were deeper at all three planes in eyes with more damage than contralateral eyes (all Ps < 0.05). LCD = lamina cribrosa depth; ONH = optic nerve head; NTG = normal tension glaucoma.

 

A case of 88-year-old female with bilateral asymmetric normal tension glaucoma.

A case of 88-year-old female with bilateral asymmetric normal tension glaucoma.

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