June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Longitudinal changes in choroidal optical coherence tomography angiography indices among young adults and children over one year.
Author Affiliations & Notes
  • Barsha Lal
    School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia
  • David Alonso-Caneiro
    School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia
  • Scott Read
    School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia
  • Andrew Carkeet
    School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia
  • Footnotes
    Commercial Relationships   Barsha Lal None; David Alonso-Caneiro None; Scott Read None; Andrew Carkeet None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1429 – F0387. doi:
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      Barsha Lal, David Alonso-Caneiro, Scott Read, Andrew Carkeet; Longitudinal changes in choroidal optical coherence tomography angiography indices among young adults and children over one year.. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1429 – F0387.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Choroidal microvasculature exhibits a significant association with axial length (AL). AL changes with age and as myopia progresses, so long-term changes in choroidal microvasculature might be expected. We conducted a 1-year prospective longitudinal study to investigate changes in choroidal microvasculature indices using optical coherence tomography angiography (OCT-A) among healthy myopic and non-myopic children and young adults.

Methods : Measurements including 3mm×3mm macular OCT-A enhanced depth scans, AL and refraction were collected at baseline and 1-year follow-up for 22 adults (18-30 years,12 myopes,10 non-myopes) and 21 children (6-15 years,11 myopes,10 non-myopes). Choriocapillaris (29 to 49 µm below retinal pigment epithelium (RPE)) and the deep choroidal layer (64 to 115 µm below RPE) en face OCT-A images were analysed to extract magnification-corrected choriocapillaris flow deficit density (FDDcc) and deep choroidal perfusion density (PDch) for sub-foveal and parafoveal zones. Changes over 1-year were compared between age groups and between refractive groups within the age groups using Mann-Whitney U.

Results : The FDDcc and PDch did not change significantly over 1-year or differ between age groups (P>0.05), however significant differences between refractive subgroups were observed. AL and spherical equivalent refraction underwent significant changes (P<0.05), with larger AL changes in children (0.20±0.27mm) than adults (0.04±0.07mm). Parafoveal FDDcc changes were significantly associated with AL changes (P=0.01) (Figure 1) and refractive groups (P=0.01) and sub-foveal PDch changes associated with refractive groups (P=0.01) in adults but not in children. Between the refractive groups, changes in sub-foveal FDDcc and PDch and parafoveal FDDcc were significantly different (P<0.05) among adults, but not in children (Figure 2).

Conclusions : Longitudinal changes in choroidal OCT-A indices were significantly associated with AL changes and refractive group only in adults, with myopes and non-myopes showing different magnitudes of change. These relationships were not found in children.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Association between choriocapillaris flow deficit density (FDDCC) and axial length changes in the age groups

Association between choriocapillaris flow deficit density (FDDCC) and axial length changes in the age groups

 

Changes in choriocapillaris flow deficit density (FDDCC) for age and refractive groups.

Changes in choriocapillaris flow deficit density (FDDCC) for age and refractive groups.

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