June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
A review of concentric macular rings seen on scanning laser ophthalmoscopy ultra-widefield pseudocolour reflectance images
Author Affiliations & Notes
  • Isuru Godakandage Isuru Ravihansa De Silva
    Medical Retina, Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Footnotes
    Commercial Relationships   Isuru De Silva None
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Investigative Ophthalmology & Visual Science June 2022, Vol.63, 992 – F0239. doi:
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      Isuru Godakandage Isuru Ravihansa De Silva; A review of concentric macular rings seen on scanning laser ophthalmoscopy ultra-widefield pseudocolour reflectance images. Invest. Ophthalmol. Vis. Sci. 2022;63(7):992 – F0239.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the relationship between foveal morphology and the presence of concentric macular rings (CMR) on ultra-widefield scanning laser ophthalmoscopy (SLO) pseudocolour images

Methods : Retrospective analysis of ultra-widefield (SLO) pseudocolour images (Optos California, Optos plc, Dunfermline, UK) performed on patients in a single tertiary care clinic, in the first half of 2021 were reviewed. Patients were included if they had spectral-domain optical coherence tomography (SD-OCT) scans (Spectralis [Heidelberg Engineering GmbH, Heidelberg, Germany) of the macula performed at the same visit. Foveal morphology, visual acuity and diagnosis were recorded.

Results : Fourteen (14) subjects met the inclusion criteria, with a mean age of 8.9 years (standard deviation 3.59, range 3 - 17 years) of whom 8 were female. Of all these patients with concentric macular rings, only 9 demonstrated some degree of foveal hypoplasia on SD-OCT. This included 6 patients with oculocutaneous albinism and one each with a diagnosis of Hermansky-Pudlak syndrome, Microphthalmia and atypical epiretinal membranes. Amongst the 5 subjects demonstrating normal foveal development despite the presence of CMRs, a molecular diagnosis was obtained in 4 which included NR2E3 (2), CHM (1), and RPGP(1). Visual acuity was better in the group with normal foveal development (avg Logmar 0.16) compared to those with foveal hypoplasia (0.47).

Conclusions : Concentric macular rings on SLO ultra-widefield pseudocolour images are infrequently reported findings, previously reported to occur in presence of foveal hypoplasia. Although these findings were more common with foveal hypoplasia, we report that they may be noted in its absence.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Concentric macular rings with foveal hypoplasia 1. Oculocutaneous albinism 2. Atypical epiretinal membranes 3. Hermansky-Pudlak syndrome 4. Microphthalmia-coloboma ; (a) cropped pseudocolour (b) SD-OCT macula.

Concentric macular rings with foveal hypoplasia 1. Oculocutaneous albinism 2. Atypical epiretinal membranes 3. Hermansky-Pudlak syndrome 4. Microphthalmia-coloboma ; (a) cropped pseudocolour (b) SD-OCT macula.

 

Concentric macular rings with no foveal hypoplasia with variable diagnosis 1. Enhanced S-cone syndrome (NR2E3) 2. X Linked Retinitis pigmentosa (RPGR) 3. Enhanced S-cone syndrome (NR2E3) 4. Infantile nystagmus syndrome ; (a) cropped pseudocolour (b) SD-OCT macula.

Concentric macular rings with no foveal hypoplasia with variable diagnosis 1. Enhanced S-cone syndrome (NR2E3) 2. X Linked Retinitis pigmentosa (RPGR) 3. Enhanced S-cone syndrome (NR2E3) 4. Infantile nystagmus syndrome ; (a) cropped pseudocolour (b) SD-OCT macula.

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