Correlation between Diopsys^® NOVA fixed-luminance flicker phase and Diagnosys^® flicker implicit time

Abstract

Purpose : Diopsys^® NOVA is a novel electroretinography (ERG) system that can perform flicker ERG testing. In this cross-sectional study, we assess the correlation between Diopsys^® NOVA fixed-luminance flicker ERG phase and Diagnosys^® Espion 2 flicker ERG implicit time measurements.

Methods : This study was a retrospective evaluation of patients with various retinal pathologies who underwent Diopsys^® NOVA fixed-luminance and Diagnosys^® Espion 2 flicker testing over a period of seven months. Patients who had an interim period of three or more months between the two tests were excluded. Patients who had any surgical intervention or change in disease activity between the two tests were excluded. Baseline patient characteristics including age, sex, and underlying diseases were collected. Pearson correlation coefficient was used for correlation analysis of values measured by the Diopsys^® NOVA and the Diagnosys^® Espion 2 flicker tests.

Results : The average Diopsys^® phase measurement was 301.76 ± 38.02° while the average Diagnosys^® implicit time measurement was 30.64 ± 4.28 milliseconds. A significant, strong negative correlation (r= -0.814, P<0.001) was observed between phase and implicit time measurements (Figure 1). Mean age of patients was 53.3 ± 24.1 years. 58% (n=7/12) of patients were female. Best corrected visual acuity ranged from 20/20 to hand motion. Ocular conditions included retinal vasculitis (n=7/22 eyes, 32%), melanoma associated retinopathy (n=2/22 eyes, 9%), panuveitis (n=2/22 eyes, 9%), autoimmune retinopathy (n=2/22 eyes, 9%), autoimmune optic neuropathy (n=2/22 eyes, 9%), non-proliferative diabetic retinopathy (n=2/22 eyes, 9%), age-related macular degeneration (n=2/22 eyes, 9%), tuberculous choroiditis (n=2/22 eyes, 9%), and retinal vein occlusion (n=1/22 eyes, 5%). Five patients (42%) had significant systemic associations including metastatic cutaneous melanoma, HLA-A29 positivity, tuberculosis, breast cancer, multiple sclerosis, and autoimmune hepatitis.

Conclusions : Higher Diopsys^® NOVA fixed-luminance flicker ERG phase values are strongly correlated with lower Diagnosys^® Espion 2 flicker ERG implicit time values. Our results suggest that Diopsys^® NOVA fixed-luminance flicker ERG phase is consistent with Diagnosys^® Espion 2 flicker ERG implicit time.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure 1: Relationship between Diopsys^® phase and Diagnosys^® implicit time.