June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Hair cortisol level as molecular biomarker in retinitis pigmentosa patients
Author Affiliations & Notes
  • Milagros Mateos
    Ophthalmology, Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
    Instituto de Oftalmobiologia Aplicada, Valladolid, Castilla y León, Spain
  • Kevin Louis Puertas-Neyra
    Instituto de Oftalmobiologia Aplicada, Valladolid, Castilla y León, Spain
  • MI Peralta-Ramírez
    Mind, Brain and Behavior Research Center (CIMCYC), Faculty of Psychology, University of Granada, Granada, Granada, Spain
  • Raquel Gonzalez-Pérez
    Pharmacology, CIBERehd, School of Pharmacy, Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Granada, Spain
  • Javier Martín-Vallejo
    Statistics, Universidad de Salamanca, Salamanca, Castilla y León, Spain
  • Carmen García-Vazquez
    Instituto de Oftalmobiologia Aplicada, Valladolid, Castilla y León, Spain
  • RM Coco
    Instituto de Oftalmobiologia Aplicada, Valladolid, Castilla y León, Spain
    Cooperative Health Network for Research in Ophthalmology (Oftared), National Institute of Health Carlos III, ISCIII, Madrid, Madrid, Spain
  • Jose-Carlos Pastor
    Instituto de Oftalmobiologia Aplicada, Valladolid, Castilla y León, Spain
    Cooperative Health Network for Research in Ophthalmology (Oftared), National Institute of Health Carlos III, ISCIII, Madrid, Madrid, Spain
  • Eva M Sobas Abad
    Instituto de Oftalmobiologia Aplicada, Valladolid, Castilla y León, Spain
  • Salvador Pastor-Idoate
    Ophthalmology, Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
    Instituto de Oftalmobiologia Aplicada, Valladolid, Castilla y León, Spain
  • Ricardo Usategui-Martín
    Instituto de Oftalmobiologia Aplicada, Valladolid, Castilla y León, Spain
    Cooperative Health Network for Research in Ophthalmology (Oftared), National Institute of Health Carlos III, ISCIII, Madrid, Madrid, Spain
  • Footnotes
    Commercial Relationships   Milagros Mateos None; Kevin Puertas-Neyra None; MI Peralta-Ramírez None; Raquel Gonzalez-Pérez None; Javier Martín-Vallejo None; Carmen García-Vazquez None; RM Coco None; Jose-Carlos Pastor None; Eva Sobas Abad None; Salvador Pastor-Idoate None; Ricardo Usategui-Martín None
  • Footnotes
    Support  GRS 1932/A/19; PID2020-114585RA-I00
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4485 – F0272. doi:
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    • Get Citation

      Milagros Mateos, Kevin Louis Puertas-Neyra, MI Peralta-Ramírez, Raquel Gonzalez-Pérez, Javier Martín-Vallejo, Carmen García-Vazquez, RM Coco, Jose-Carlos Pastor, Eva M Sobas Abad, Salvador Pastor-Idoate, Ricardo Usategui-Martín; Hair cortisol level as molecular biomarker in retinitis pigmentosa patients. Invest. Ophthalmol. Vis. Sci. 2022;63(7):4485 – F0272.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Retinitis pigmentosa (RP) patients commonly experience negative psychological states due to their progressive and unpredictable loss of vision and visual variations related to stress. The aim of this study was to examine hair cortisol concentrations (HCCs), which is usually associated with chronic stress, pretending to unveil possible associations between underlying psychological factors and disease severity in RP patients.

Methods : Seventy-eight RP patients and 148 healthy controls were included in this A complete ophthalmological exam was performed in all patients to grade into severity disease groups. Perceived stress and trait-anxiety were measured by the State-Trait Anxiety Inventory (STAI) questionnaire.

Results : Fifty-two (67%) patients had severe RP and 26 (33%) mild-moderate RP. Fifty-eight (58,9%) patients reported severely levels of stress and 18 (23.,1%) highly levels assessed by STAI questionnaire. RP patients exhibited higher HCCs (500.04±120.99 pg/mg) than in controls (136.17±60.51 pg/mg; p<0.001). Severe RP patients had significant higher HCCs than mild-moderate patients differing in 274.27pg/mg (p<0.001). There were no differences between RP severity grade and perceived anxiety levels in the questionaries. Group differences were not affected by relevant covariates (age, grade of severity, stress status, and gender).

Conclusions : HCC seems an effective biomarker associated with chronic stress in RP patients. This study shows that HCC in patients with RP are elevated compared to population-based controls, and association between HCC and RP severity was found. Future research is needed to characterize the effect of untreated negative psychological states on increased variability of vision and progression of the disease if any.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Mean ± SD Log-transformed HCC and differences between groups. A) HCC was significantly higher in RP patients 2.62 ± 0.14 Log10 pg/mg than in controls 1.99 ± 0.23 Log10 pg/mg (p<0.001). B) RP patients with a severe grade of disease also had superior concentrations than mild-moderate grade (severe RP: 2.71 ± 0.12 Log10 pg/mg; mild-moderate RP: 2.43 ± 1.17 Log10 pg/mg; p=0.011). C) There also existed statistical and clinical differences between anxiety levels, severe group obtained 2.70 ± 0.24 Log10 pg/mg vs. 2.49 ± 0.19 Log10 pg/mg from high anxiety group (p=0.001).

Mean ± SD Log-transformed HCC and differences between groups. A) HCC was significantly higher in RP patients 2.62 ± 0.14 Log10 pg/mg than in controls 1.99 ± 0.23 Log10 pg/mg (p<0.001). B) RP patients with a severe grade of disease also had superior concentrations than mild-moderate grade (severe RP: 2.71 ± 0.12 Log10 pg/mg; mild-moderate RP: 2.43 ± 1.17 Log10 pg/mg; p=0.011). C) There also existed statistical and clinical differences between anxiety levels, severe group obtained 2.70 ± 0.24 Log10 pg/mg vs. 2.49 ± 0.19 Log10 pg/mg from high anxiety group (p=0.001).

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