June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Association among basement membrane diseases of the eye: Fuchs endothelial corneal dystrophy (FECD), anterior basement membrane dystrophy (ABMD) and age-related macular degeneration (AMD)
Author Affiliations & Notes
  • Michael Shi
    Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, United States
  • Henry Greyner-Almeida
    Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, United States
  • Alexandra Sima
    Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, United States
  • Teigen Ruster
    Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, United States
  • Patricia Gianfagna
    Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, United States
  • Brendan Plotke
    Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, United States
  • Jack M Sullivan
    Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, United States
    Research Service, VA Western New York Healthcare System, Buffalo, New York, United States
  • Amy E Millen
    Epidemiology and Environmental Health, University at Buffalo School of Public Health and Health Professions, Buffalo, New York, United States
  • Sangita P Patel
    Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, United States
    Research Service, VA Western New York Healthcare System, Buffalo, New York, United States
  • Footnotes
    Commercial Relationships   Michael Shi None; Henry Greyner-Almeida None; Alexandra Sima None; Teigen Ruster None; Patricia Gianfagna None; Brendan Plotke None; Jack Sullivan None; Amy Millen None; Sangita Patel None
  • Footnotes
    Support  NIH K08 EY029007; Jacobs School of Medicine and Biomedical Sciences, Summer Research Fellowships
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3547 – A0127. doi:
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      Michael Shi, Henry Greyner-Almeida, Alexandra Sima, Teigen Ruster, Patricia Gianfagna, Brendan Plotke, Jack M Sullivan, Amy E Millen, Sangita P Patel; Association among basement membrane diseases of the eye: Fuchs endothelial corneal dystrophy (FECD), anterior basement membrane dystrophy (ABMD) and age-related macular degeneration (AMD). Invest. Ophthalmol. Vis. Sci. 2022;63(7):3547 – A0127.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The pathophysiologic processes in FECD, ABMD, and AMD all involve basement membrane dysfunction. We tested the hypothesis that FECD is independently associated with presence of ABMD and AMD.

Methods : This is a single-center cross-sectional study, approved by the University at Buffalo IRB. A single ophthalmologist for this study systematically examined consecutive patients for FECD, ABMD and AMD. We enrolled individuals >18 years old with documented exam findings for all three ocular diseases, and excluded those with bilateral corneal scarring (preventing full exam) and penetrating keratoplasty. FECD was graded (modified Krachmer scale) based on findings of central corneal guttae (0=absent to 6=confluent with corneal edema). Patients that had undergone endothelial keratoplasty were assigned FECD grade 7. Patients with characteristic map-dot fingerprint changes of the epithelium were considered ABMD positive. Patients with macular drusen, pigmentary changes, or atrophy of the retinal pigment epithelium were considered AMD positive. Those with sparse small drusen or absence of pigment abnormalities were considered AMD negative. Poisson regression with robust estimation was used to estimate crude and age-adjusted prevalence ratios and 95% confidence intervals of ABMD, AMD or both among participants with different severity levels of FECD compared to individuals with absent FECD (grade 0 used as reference group). Significance was set at p<0.05.

Results : Among 435 participants (ages 18-96, mean 61 years; 262 female, Table 1), the prevalence of having ABMD, AMD, or both, was greater in those with FECD grades of 3-5, 7, and ≥ 1 vs. 0 (Table 2). After age adjustment, we continued to find a statistically significant increased prevalence of ABMD, AMD or both among those with FECD grade 7 vs. 0 (Table 2).

Conclusions : Advanced FECD may be significantly associated with ABMD and AMD. However, these findings seem to be driven by associations in those who have undergone corneal transplantation, suggesting a role for corneal transplantation in the progression of ABMD and AMD.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

 

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