June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Association Between Ganglion Cell Complex Thinning and Vision-Related Quality of Life in Glaucoma
Author Affiliations & Notes
  • Takashi Nishida
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Sasan Moghimi
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Vahid Mohammadzadeh
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Jo-Hsuan Wu
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Maya L.M. Yamane
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Alireza Kamalipour
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Golnoush Mamoudinezhad
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Eleonora Micheletti
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Jeffrey M Liebmann
    Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, United States
  • Massimo A. Fazio
    Bernard School of Medicine, University of Alabama-Birmingham, Birmingham, Alabama, United States
  • Christopher A Girkin
    Bernard School of Medicine, University of Alabama-Birmingham, Birmingham, Alabama, United States
  • Linda M Zangwill
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Robert N Weinreb
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Takashi Nishida None; Sasan Moghimi None; Vahid Mohammadzadeh None; Jo-Hsuan Wu None; Maya Yamane None; Alireza Kamalipour None; Golnoush Mamoudinezhad None; Eleonora Micheletti None; Jeffrey Liebmann Alcon, Allergan, Carl Zeiss Meditec, Heidelberg Engineering, Code C (Consultant/Contractor), Bausch & Lomb, Carl Zeiss Meditec, Heidelberg Engineering, National Eye Institute, Novartis, Optovue, Reichert Technologies, Research to Prevent Blindness, Code F (Financial Support); Massimo Fazio National Eye Institute, EyeSight Foundation of Alabama, Research to Prevent Blindness, Heidelberg Engineering GmbH, Code F (Financial Support); Christopher Girkin National Eye Institute, EyeSight Foundation of Alabama, Research to Prevent Blindness, Heidelberg Engineering GmbH, Code F (Financial Support); Linda Zangwill Abbvie Inc., Digital Diagnostics, Code C (Consultant/Contractor), National Eye Institute, Carl Zeiss Meditec Inc., Heidelberg Engineering GmbH, Optovue Inc., Topcon Medical Systems Inc., Code F (Financial Support), Zeiss Meditec, Code P (Patent); Robert Weinreb Aerie Pharmaceuticals, Allergan, Eyenovia, Code C (Consultant/Contractor), Heidelberg Engineering, Carl Zeiss Meditec, Konan Medical, Optovue, Centervue, Bausch&Lomb, Topcon, Code F (Financial Support), Toromedes, Zeiss Meditec, Code P (Patent)
  • Footnotes
    Support  National Eye Institute R01EY029058, R01EY11008, R01EY19869, R01EY027510, R01EY026574, EY018926, P30EY022589, Unrestricted grants from Research to Prevent Blindness (New York, NY), EyeSight Foundation of Alabama; Research to Prevent Blindness, Tobacco-Related Disease Research Program T31IP1511
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3322 – F0131. doi:
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    • Get Citation

      Takashi Nishida, Sasan Moghimi, Vahid Mohammadzadeh, Jo-Hsuan Wu, Maya L.M. Yamane, Alireza Kamalipour, Golnoush Mamoudinezhad, Eleonora Micheletti, Jeffrey M Liebmann, Massimo A. Fazio, Christopher A Girkin, Linda M Zangwill, Robert N Weinreb; Association Between Ganglion Cell Complex Thinning and Vision-Related Quality of Life in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3322 – F0131.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the association between the rate of ganglion cell complex (GCC) thinning and the vision function questionnaire (VFQ) in glaucoma.

Methods : In this longitudinal study, 236 eyes of 118 patients with diagnosed or suspected glaucoma followed up for an average of 4.1 years were enrolled from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study. The VFQ was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ) at the last follow-up visit. GCC thickness was derived from macular optical coherence tomography scans and averaged within 3 circle areas (3.4-degree, 5.6-degree, and 6.8-degree from the fovea) and superior and inferior hemiregions. Linear mixed-effects models were used to investigate the association between the rate of GCC thinning and Rasch-calibrated VFQ score.

Results : Faster rate of global GCC thinning was significantly associated with higher disability of Rasch-calibrated NEI-VFQ score (-0.31 (95% CI) (-0.57, -0.04) um/year per 100 score; P=.02). When stratified by degrees from the fovea, the 3.4-degree area had the highest association with the composite NEI-VFQ Rasch-calibrated score (-0.52 (-0.91, -0.13) um/year per 100 score: P=.009) followed by the 5.6-degree (-0.34 (-0.62, -0.06) um/year per 100 score: P=.02) and 6.8-degree (-0.16 (-0.32, 0.00) um/year per 100 score: P=.05).

Conclusions : The faster and more central locations of GCC thinning are associated with vision-related quality of life in glaucoma patients. Monitoring macular structure provide useful information in determining the risk of functional impairment in glaucoma.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Table. Association between GCC slopes of better eye and the NEI VFQ Rasch-calibrated score

Table. Association between GCC slopes of better eye and the NEI VFQ Rasch-calibrated score

 

Figure. The left image depicts the 3 areas defined for accounting for the macular thickness changes as a function of distance from the fovea: circle 1, 3.4 degree; circle 2, 5.6 degree; and circle 3, 6.8 degree. The right image depicts the inferior and superior hemiregions in this study.

Figure. The left image depicts the 3 areas defined for accounting for the macular thickness changes as a function of distance from the fovea: circle 1, 3.4 degree; circle 2, 5.6 degree; and circle 3, 6.8 degree. The right image depicts the inferior and superior hemiregions in this study.

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