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Leana Rohman, Marco Ruggeri, Arthur Ho, Jean-Marie Parel, Fabrice Manns; Quantification of lens thickness microfluctuations in young and pre-presbyopic eyes using dynamic OCT biometry. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3069 – F0541.
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© ARVO (1962-2015); The Authors (2016-present)
According to earlier studies utilizing ultrasound, analysis of the dynamics of the lens can provide insights into the lens' mechanical properties and their changes over time, causing presbyopia. This study aims to determine if they are differences in the mechanical microfluctuations of the lens between young and pre-presbyopic subjects.
Using a custom-built extended depth OCT system (Ruggeri et al., BOE, 2012) and following an IRB-approved protocol, we imaged the lens of the left eye of 3 young subjects (age range: 21 to 25 years; MSE: -0.38 to -3.38 D ) and 3 pre-presbyopic subjects (age range: 38 to 45 years; MSE: -0.75 to -4.38 D). We recorded 500 OCT images of the central 2 mm zone of the lens at 50 frames/s (10 s recording session) for each participant at different accommodative demands (young subjects: 0D, 2D, 4D, 7D; pre-presbyopic subjects: 0D, 4D). Each image consisted of 170 A-lines. For each frame, the lens thickness was quantified using a custom-made, semi-automatic MATLAB application. The power spectrum of the lens microfluctuations is calculated by using the Fourier Transform in MATLAB. Then, the microfluctuations are assessed by calculating the area under the power spectrum curve between 0 and 4 Hz.
The amplitude of lens microfluctuations was higher in the accommodated state than in the relaxed state in both age groups. Compared to the relaxed state, the average amplitude of microfluctuations for young subjects is 2.3 times greater at 4D, while for pre-presbyopic subjects it is 1.8 times greater (Fig.1). For young subjects, the microfluctuations of the lens do not increase with increasing accommodation demand once it has reached an accommodative state (Fig. 2).
The results demonstrate the feasibility of quantifying lens thickness microfluctuations using dynamic OCT. Also, the study suggests that the magnitude of lens microfluctuations is larger in the accommodated state and in young compared to pre-presbyopic eyes. Moreover, the amplitude of microfluctuations in the accommodated state is independent of the accommodative response.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.
Fig. 1 - Comparison of the evolution of the microfluctuations between young and pre-presbyopic subjects
Fig. 2 - Evolution of the lens microfluctuations and lens thickness in young subjects for different accommodative demands
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