June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Automated detection of morphologic changes on SD-OCT leading toward outer retinal atrophy in intermediate age-related macular degeneration in the prospective PINNACLE trial
Author Affiliations & Notes
  • Sophie Riedl
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Wolf-Dieter Vogl
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Oliver Leingang
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Hrvoje Bogunovic
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Lars Fritsche
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States
  • Toby Prevost
    King's College London, London, London, United Kingdom
  • Daniel Rueckert
    Department of Computing, Imperial College London, London, London, United Kingdom
  • Hendrik P Scholl
    Institute of Molecular and Clinical Ophthalmology Basel, Basel, Basel-Stadt, Switzerland
    Department of Ophthalmology, Universitat Basel, Basel, Basel-Stadt, Switzerland
  • Sobha Sivaprasad
    NIHR Moorfields Biomedical Research Centre, London, Greater London, United Kingdom
  • Andrew J Lotery
    University of Southampton Faculty of Medicine, Southampton, Southampton, United Kingdom
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Footnotes
    Commercial Relationships   Sophie Riedl None; Wolf-Dieter Vogl None; Oliver Leingang None; Hrvoje Bogunovic None; Lars Fritsche None; Toby Prevost None; Daniel Rueckert None; Hendrik Scholl None; Sobha Sivaprasad None; Andrew Lotery None; Ursula Schmidt-Erfurth None
  • Footnotes
    Support   Wellcome Trust Grant [210572/Z/18/Z]
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2319. doi:
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      Sophie Riedl, Wolf-Dieter Vogl, Oliver Leingang, Hrvoje Bogunovic, Lars Fritsche, Toby Prevost, Daniel Rueckert, Hendrik P Scholl, Sobha Sivaprasad, Andrew J Lotery, Ursula Schmidt-Erfurth; Automated detection of morphologic changes on SD-OCT leading toward outer retinal atrophy in intermediate age-related macular degeneration in the prospective PINNACLE trial. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2319.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report preliminary data on the automated detection of focal morphologic changes - Focal Events - on spectral domain-optical coherence tomography (SD-OCT) in the ongoing PINNACLE trial, a prospective observational study in intermediate age-related macular degeneration (NCT04269304).

Methods : Four automated algorithms, segmenting drusen, photoreceptors, hypertransmission, as well as intra- and subretinal fluid are applied. Pre-specified post-processing criteria define four types of Focal Events, as shown in Figure 1, for which eyes are screened at every 4-monthly visit in the prospective PINNACLE trial. We herein report interim descriptive data on the frequency and sequence of Focal Event occurrence.

Results : Volume OCT data of 855 follow-up visits of 334 eyes of 259 patients have so far been screened for the occurrence of Focal Events. Drusen regression (DR) was detected in 3%, photoreceptor loss + hypertransmission (PLH) in 11%, subretinal fluid in 1% and intraretinal fluid in less than 1% of visits. In 44 eyes Focal Events occurred at more than one follow-up visit. The majority (52%) of such sequential events consisted of sole recurrence of PLH, followed by 11% of cases in which PLH was followed by a combination of PLH and DR. A representative example case is shown in Figure 2.

Conclusions : The established processing pipeline has shown reliable detection of predefined morphologic changes. The occurrence of sequential non-fluid related Focal Events, showing aggravation of outer retinal atrophy, as well as atrophic signs preceding drusen regression and vice versa, demonstrate these subtle changes to present meaningful events along progressive outer retinal degeneration. Once prospective data collection is completed, evaluation of the predictive value of Focal Events for the progression toward late non-neovascular as well as neovascular AMD will be performed.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

 

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