Abstract
Purpose :
To report quantitative and quantitative analysis of Haller vessel layer using 3-dimensional (3-D) model of choroidal vasculature in healthy subjects.
Methods :
A retrospective study of patients (n = 14) of healthy subjects with no history of previous retinal disease underwent swept-source optical coherence tomography. Previously validated algorithm was used to create a 3-D Haller vessel reconstruction was constructed. Two independent personnel evaluated the images of the Haller vessels via a three dimensional representation on MeshLab® and graded them on qualitative criterias including symmetry, hot areas showing thicker vessels, branching, rarefaction, and focal constriction. Quantitative analysis was performed using heat maps which included mean, relative distribution (range) of radius, quadrant analysis and curvature analysis.
Results :
The average age of the patient was 38.4 ± 16.2. The average of the minimum (15.0 ± 1.2 µm) and maximum (174.1± 6.6 µm) of the vessels was calculated. Qualitative analysis on Haller vessels based on symmetricity (100% symmetric), branching (42.9% occasional; 57.1% moderate), rarefaction (50.0% absent; 42.9% mild-moderate; 7.1% severe), focal hot area (28.6% absent; 57.1% few; 14.3% absent), course of vessels i.e., parallel to each other (92.9% yes; 7.1% no), and focal vascular constriction (14.3% yes; 85.7% no) was performed. Further analysis on other quantitative parameters is underway.
Conclusions :
Healthy subjects largely had symmetric distribution with parallel arrangement of Haller layer blood vessels with mild branching and rarefaction with few focal hot areas and focal constriction. Normative database for different age groups for Haller vessel analysis will be established.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.