June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Three dimensional analysis of Haller vessels in healthy eyes
Author Affiliations & Notes
  • Anindya Samanta
    Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas, United States
  • Mohammed Nasar Ibrahim
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Sumit Singh
    Nilima Sinha Medical College & Hospital, India
  • Amrish Selvam
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Mohammed Abdul Rasheed
    LV Prasad Eye Institute, Hyderabad, Telangana, India
  • Jose Alain Sahel
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Kiran Kumar Vupparaboina
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Jay Chhablani
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Anindya Samanta None; Mohammed Ibrahim None; Sumit Singh None; Amrish Selvam None; Mohammed Abdul Rasheed None; Jose Sahel None; Kiran Vupparaboina None; Jay Chhablani None
  • Footnotes
    Support  This work was supported by NIH CORE Grant P30 EY08098 to the Department of Ophthalmology, the Eye and Ear Foundation of Pittsburgh, and from an unrestricted grant from Research to Prevent Blindness, New York, NY.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2094 – F0083. doi:
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      Anindya Samanta, Mohammed Nasar Ibrahim, Sumit Singh, Amrish Selvam, Mohammed Abdul Rasheed, Jose Alain Sahel, Kiran Kumar Vupparaboina, Jay Chhablani; Three dimensional analysis of Haller vessels in healthy eyes. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2094 – F0083.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report quantitative and quantitative analysis of Haller vessel layer using 3-dimensional (3-D) model of choroidal vasculature in healthy subjects.

Methods : A retrospective study of patients (n = 14) of healthy subjects with no history of previous retinal disease underwent swept-source optical coherence tomography. Previously validated algorithm was used to create a 3-D Haller vessel reconstruction was constructed. Two independent personnel evaluated the images of the Haller vessels via a three dimensional representation on MeshLab® and graded them on qualitative criterias including symmetry, hot areas showing thicker vessels, branching, rarefaction, and focal constriction. Quantitative analysis was performed using heat maps which included mean, relative distribution (range) of radius, quadrant analysis and curvature analysis.

Results : The average age of the patient was 38.4 ± 16.2. The average of the minimum (15.0 ± 1.2 µm) and maximum (174.1± 6.6 µm) of the vessels was calculated. Qualitative analysis on Haller vessels based on symmetricity (100% symmetric), branching (42.9% occasional; 57.1% moderate), rarefaction (50.0% absent; 42.9% mild-moderate; 7.1% severe), focal hot area (28.6% absent; 57.1% few; 14.3% absent), course of vessels i.e., parallel to each other (92.9% yes; 7.1% no), and focal vascular constriction (14.3% yes; 85.7% no) was performed. Further analysis on other quantitative parameters is underway.

Conclusions : Healthy subjects largely had symmetric distribution with parallel arrangement of Haller layer blood vessels with mild branching and rarefaction with few focal hot areas and focal constriction. Normative database for different age groups for Haller vessel analysis will be established.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

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