June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Relationship between contrast sensitivity and visual field mean deviation
Author Affiliations & Notes
  • Joyce Kang
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Sandra Freeman
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Sofia De Arrigunaga
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Yan Zhao
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Ana M. Roldan
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Tobias Elze
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • David S Friedman
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Daniel Liebman
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Dolly Chang
    Genentech Inc, South San Francisco, California, United States
    Stanford University School of Medicine, Stanford, California, United States
  • Michael M. Lin
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Joyce Kang None; Sandra Freeman None; Sofia De Arrigunaga None; Yan Zhao None; Ana Roldan None; Tobias Elze Genentech Inc., Code F (Financial Support); David Friedman Bausch and Lomb, W L Gore and Associates, Life Biosciences, Thea Pharmaceuticals, Code C (Consultant/Contractor), Genentech Inc, Zeiss Meditech, Code F (Financial Support); Daniel Liebman None; Dolly Chang Genentech Inc., Code E (Employment); Michael Lin None
  • Footnotes
    Support  Genentech, Inc. (San Francisco, CA, USA)
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1261 – A0401. doi:
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    • Get Citation

      Joyce Kang, Sandra Freeman, Sofia De Arrigunaga, Yan Zhao, Ana M. Roldan, Tobias Elze, David S Friedman, Daniel Liebman, Dolly Chang, Michael M. Lin; Relationship between contrast sensitivity and visual field mean deviation. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1261 – A0401.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Mean contrast sensitivity (CS) and area under the log CS function (AULCSF) parameters may help evaluate visual function in patients with glaucoma, yet they are rarely performed in routine clinical care. The quick CS function (qCSF) test (Adaptive Sensory Technology, San Diego, CA, USA) is a Bayesian adaptive procedure that estimates AULCSF by measuring CS at different spatial frequencies and modeling log CS as a function of stimulus size. We analyzed the relationship between qCSF test outputs and visual field mean deviation (MD).

Methods : In this observational study, subjects with visual acuity 20/40 or better and a diagnosis of glaucoma or glaucoma suspect performed the qCSF test. All subjects were reliable, experienced HFA testers. qCSF reports AULCSF and the individual CS recorded at 1.0, 1.5, 3.0, 6.0, 12.0 and 18.0 cycles per degree (CPD). We created a scatterplot with AULCSF as a function of each subject’s MD and fit linear regression at each CPD to evaluate the effect of MD on CS, then adjusted for intraocular lens status.

Results : MD averaged -3.16 (± 3.90) dB for 54 eyes of 54 subjects with mean age 61 years (range 30-71) and was not correlated with AULCSF (P = 0.15, Figure 1). Better MD was associated with better CS at 1.0, 1.5, and 3.0 CPD (Figure 2), but these correlations were weak. When intraocular lens status was added to the model, it was correlated with CS at 1.0 and 1.5 CPD, and MD was no longer correlated with CS.

Conclusions : HFA MD and AULCSF were not correlated in this population with mostly early or no VF defects. MD was correlated with CS at lower CPD (1.0, 1.5, 3.0). This association was no longer statistically significant when adjusting for intraocular lens status. The mild glaucoma severity in this cohort may have limited the ability to detect a relationship between CS and MD, and any relationship was overshadowed by intraocular lens status. At higher CPD, CS is less correlated with MD and intraocular lens status. The results of this preliminary study were limited by the overall healthy population and apply only within the bounds of the tested cohort.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure 1: Scatterplot of mean deviation (MD) as a function of AULCSF for 54 study eyes.

Figure 1: Scatterplot of mean deviation (MD) as a function of AULCSF for 54 study eyes.

 

Figure 2: Linear regression for contrast sensitivity functions (spatial frequencies at 1.0, 1.5, and 3.0 CPD) measured in 54 eyes.

Figure 2: Linear regression for contrast sensitivity functions (spatial frequencies at 1.0, 1.5, and 3.0 CPD) measured in 54 eyes.

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