Investigative Ophthalmology & Visual Science Cover Image for Volume 63, Issue 7
June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Mesopic and Scotopic Light Sensitivity Loss Associated with Intraretinal Hyperreflective Foci in Age-related Macular Degeneration
Xiaolin Wang; Yuhua Zhang; Srinivas R Sadda; David Sarraf; Michael S Ip; Giulia Corradetti; Ruixue Liu; Shin Kadomoto; Sujin Hoshi
Author Affiliations & Notes
  • Xiaolin Wang
    Doheny Eye Institute, Los Angeles, California, United States
  • Yuhua Zhang
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • David Sarraf
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
    Jules Stein Eye Institute, Los Angeles, California, United States
  • Michael S Ip
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Giulia Corradetti
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Ruixue Liu
    Doheny Eye Institute, Los Angeles, California, United States
  • Shin Kadomoto
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Sujin Hoshi
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Xiaolin Wang None; Yuhua Zhang None; Srinivas Sadda Amgen, Allergan, Genentech/Roche, Iveric, Oxurion, Novartis, Regeneron, Bayer, 4DMT, Centervue, Heidelberg, Optos, Merck, Apellis, Astellas, Code C (Consultant/Contractor), Nidek, Topcon, Heidelberg, Carl Zeiss Meditec, Optos, Centervue, Code F (Financial Support), Carl Zeiss Meditec, Nidek, Code R (Recipient); David Sarraf Amgen, Bayer, Genentech, Iveric Bio, Novartis, Optovue, Topcon, Code C (Consultant/Contractor), Amgen, Boehringer, Genentech, Heidelberg, Optovue, Regeneron, Code F (Financial Support); Michael Ip Boehringer Ingelheim, Thrombogenics, Quark, Omeros, Allergan, Amgen, Astellas, Alimera, Code C (Consultant/Contractor), Novartis, Genentech, Clearside, Biogen, Code F (Financial Support); Giulia Corradetti None; Ruixue Liu None; Shin Kadomoto None; Sujin Hoshi Nipro, Machida, logic and design, Code C (Consultant/Contractor), Alcon Japan, Code F (Financial Support), 2017-121307, Code P (Patent)
  • Footnotes
    Support  National Institute of Health (R01EY024378), W. F. Keck Foundation, Carl Marshall Reeves & Mildred Almen Reeves foundation, and Research to Prevent Blindness/Dr. H. James and Carole Free Catalyst Award for Innovative Research Approaches for AMD.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 879. doi:
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      Xiaolin Wang, Yuhua Zhang, Srinivas R Sadda, David Sarraf, Michael S Ip, Giulia Corradetti, Ruixue Liu, Shin Kadomoto, Sujin Hoshi; Mesopic and Scotopic Light Sensitivity Loss Associated with Intraretinal Hyperreflective Foci in Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2022;63(7):879.

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Abstract

Purpose : Intraretinal hyperreflective foci (IHF) on optical coherence tomography (OCT) in eyes with intermediate age-related macular degeneration (AMD) are associated with a higher risk for progression to advanced AMD. This study evaluates the impact of IHF on cone- and rod-mediated vision in patients with intermediate AMD using mesopic and scotopic microperimetry and correlate the findings with retinal structures revealed by multimodal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO).

Methods : In a retrospective study involving 225 eyes of 141 subjects with AMD, IHF were identified on spectral domain OCT B-scans in 123 eyes of 69 subjects, aged 77.3 ± 7.3 years old. Lesions associated with AMD such as drusen and subretinal drusenoid deposits (SDD) were assessed by color fundus photographs, infrared reflectance, blue-light autofluorescence, and OCT. Cone photoreceptor structure was examined by AOSLO. Cone- and rod-mediated sensitivity was tested using a microperimeter (MP1-S, Nidek) under mesopic and scotopic conditions in 16 eyes of 16 subjects with intermediate AMD (grades 5 to 8 in the AREDS 9-step severity scale). Mesopic and scotopic light sensitivity tested in the retinal areas with and without IHF but with a similar SDD/drusen load were compared in the same eye.

Results : Retinal areas with IHF exhibited significantly reduced mesopic (16.92 ± 5.59 dB vs. 18.62 ± 4.73 dB, p = 0.0003) and scotopic (8.31 ± 5.72 dB vs. 9.70 ± 5.63 dB, p = 0.0087) light sensitivity, in comparison to those without IHF. AOSLO revealed disrupted cone photoreceptor structure in areas with IHF and the photoreceptor mosaic was largely not visible in regions with IHF (Figure).

Conclusions : IHF are associated with significant loss of visual function and photoreceptor degeneration in eyes with intermediate AMD. Larger prospective longitudinal studies are required to investigate the pathogenesis and sequence of events leading to the development of IHF and associated photoreceptor loss.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure. Multimodal imaging of intraretinal hyperreflective foci (IHF), infrared reflectance image (left top), OCT (left bottom) and AOSLO (right). Green line indicates where the OCT-B scan was taken. Yellow box shows retinal area imaged by AOSLO. The arrowheads point to the IHF.
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Figure. Multimodal imaging of intraretinal hyperreflective foci (IHF), infrared reflectance image (left top), OCT (left bottom) and AOSLO (right). Green line indicates where the OCT-B scan was taken. Yellow box shows retinal area imaged by AOSLO. The arrowheads point to the IHF.

Figure. Multimodal imaging of intraretinal hyperreflective foci (IHF), infrared reflectance image (left top), OCT (left bottom) and AOSLO (right). Green line indicates where the OCT-B scan was taken. Yellow box shows retinal area imaged by AOSLO. The arrowheads point to the IHF.

Figure. Multimodal imaging of intraretinal hyperreflective foci (IHF), infrared reflectance image (left top), OCT (left bottom) and AOSLO (right). Green line indicates where the OCT-B scan was taken. Yellow box shows retinal area imaged by AOSLO. The arrowheads point to the IHF.
View OriginalDownload Slide

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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