June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Antifouling Studies of Lehfilcon A Silicone Hydrogel Contact Lens
Author Affiliations & Notes
  • Shuang Liang
    Alcon Laboratories Inc, Fort Worth, Texas, United States
  • Amanda Shows
    Alcon Laboratories Inc, Fort Worth, Texas, United States
  • Daniel Dunbar
    Alcon Laboratories Inc, Fort Worth, Texas, United States
  • Vinay Sharma
    Alcon Laboratories Inc, Fort Worth, Texas, United States
  • Charlie Xinfeng Shi
    Alcon Laboratories Inc, Fort Worth, Texas, United States
  • James Wu
    Alcon Laboratories Inc, Fort Worth, Texas, United States
  • Footnotes
    Commercial Relationships   Shuang Liang Alcon, Code E (Employment); Amanda Shows Alcon, Code E (Employment); Daniel Dunbar Alcon, Code E (Employment); Vinay Sharma Alcon, Code E (Employment); Charlie Shi Alcon, Code E (Employment); James Wu Alcon, Code E (Employment)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 532 – A0230. doi:
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      Shuang Liang, Amanda Shows, Daniel Dunbar, Vinay Sharma, Charlie Xinfeng Shi, James Wu; Antifouling Studies of Lehfilcon A Silicone Hydrogel Contact Lens. Invest. Ophthalmol. Vis. Sci. 2022;63(7):532 – A0230.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : A new silicone hydrogel (SiHy) material, lehfilcon A (TOTAL30®) with surface modification of a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, was recently developed. This study was designed to evaluate the in vitro surface biological interactions as well as their impact on tear film stability on the surface of lehfilcon A and other reusable SiHy materials.

Methods : The surface structures of lehfilcon A, comfilcon A, senofilcon A, senofilcon C, and samfilcon A contact lenses were imaged using Atomic Force Microscopy (AFM). After fouling in an artificial tear lipid solution, the distributions of fluorescently labeled non-polar lipids on the entire lenses as well as the cross-sections of these SiHy materials were visualized and quantified in three-dimensional (3D) via confocal laser scanning microscopy (CLSM). The in vitro tear film stability on the fouled lens surface was further assessed using a modified multifunctional topographer method.

Results : Lehfilcon A contact lenses exhibited distinctive surface features and topographies resulting from its densely packed MPC polymer units, which was not seen on other reusable SiHy materials. Fluorescent intensity measurements of 3D CLSM images (Figure 1) showed that lipid deposition on the lens surface was significantly less for lehfilcon A compared to the other reusable SiHy materials (p<0.05 for all). Furthermore, lehfilcon A demonstrated a significantly longer surface moisture break up time than other tested contact lenses in the in vitro topography videos (19 s vs. <5 s, p<0.05 for all).

Conclusions : The hydrophilic nature of the MPC polymer layer provided an antifouling surface feature for lehfilcon A contact lenses, which delivered greater in vitro tear film stability than other reusable SiHy contact lenses. These exceptional characteristics may help achieve outstanding on-eye performance for this new SiHy contact lens.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

Figure 1: Surface and core lipid deposition on reusable contact lenses. Representative images of in vitro fouling test of lenses in A) whole lens top view imaging and B) cross section imaging of full thickness lenses after exposure to fluorescently labeled non-polar lipids, cholesteryl ester (CE) and triglyceride (TAG), and visualized on a confocal microscope to show both core and surface lipid deposition.

Figure 1: Surface and core lipid deposition on reusable contact lenses. Representative images of in vitro fouling test of lenses in A) whole lens top view imaging and B) cross section imaging of full thickness lenses after exposure to fluorescently labeled non-polar lipids, cholesteryl ester (CE) and triglyceride (TAG), and visualized on a confocal microscope to show both core and surface lipid deposition.

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