June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Dacryocystitis: an update on microbiology and drug susceptibility
Author Affiliations & Notes
  • Tzu-yu Chiu
    Ophthalmology, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Kaohsiung Medical University School of Medicine, Kaohsiung, Taiwan
  • Chia-Ching Lin
    Ophthalmology, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan
  • Footnotes
    Commercial Relationships   Tzu-yu Chiu None; Chia-Ching Lin None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3554 – A0441. doi:
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      Tzu-yu Chiu, Chia-Ching Lin; Dacryocystitis: an update on microbiology and drug susceptibility. Invest. Ophthalmol. Vis. Sci. 2022;63(7):3554 – A0441.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : More accessible medical environments may change the microbiology of dacryocystitis. The aim of our study was to identify the changing trends in microorganisms in lacrimal sac infections and examine their susceptibilities against currently recommended antibiotics.

Methods : Patients who admitted under diagnosis of dacryocystitis between 2011 and 2021 at Kaohsiung Medical University Hospital, a tertiary medical center, were retrospectively reviewed. The pus cultures collected from these patients were then evaluated to determine the types of microorganisms and their antimicrobial susceptibilities.

Results : In this study, a total of 67 patients hospitalized with dacryocystitis were evaluated, which was more common in females than in males (83.58% vs 16.41%).
From 65 pus samples, 64 microorganisms were isolated. The rate of positive culture was 87.7% and mix culture was 10.76%. The proportion of gram positive and negative isolates was nearly equal (51.56% vs 46.88%). The three most frequently isolated microorganisms were Staphylococcus aureus (23.43%) followed by Pseudomonas aeruginosa (20.31%), Staphylococcus epidermidis (7.81%) and Escherichia Coli (7.81%). An incidence of oxacillin-resistance Staphylococcus species in was 65.21%. Sensitivity of common antibiotics for aerobic bacteria is 34.10% in ampicillin-sulbactum, 50% in cefazolin, 29.63% in erythromycin and 48.14% in tetracycline.

Conclusions : Staphylococcus species, especially S. aureus, is the major pathologic microorganism in dacryocystitis. Vancomycin, cefoperazone-sulbactum and imipenum are the most sensitive antibiotics against most common isolated microorganisms in our study. The high prevalence of oxacillin-resistance and increasing isolation of Pseudomonas aeruginosa, could provide us a reference for empirical antibiotics selection.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

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