June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Adaptive optics scanning laser ophthalmoscopy of photoreceptor structure perturbation by acquired vitelliform lesions
Author Affiliations & Notes
  • Sujin Hoshi
    Doheny Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology, Tsukuba Daigaku Igaku Iryokei, Tsukuba, Ibaraki, Japan
  • Xiaolin Wang
    Doheny Eye Institute, Los Angeles, California, United States
  • Shin Kadomoto
    Doheny Eye Institute, Los Angeles, California, United States
    Department of Ophthalmology and Visual Sccience, Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu, Kyoto, Kyoto, Japan
  • Ruixue Liu
    Doheny Eye Institute, Los Angeles, California, United States
  • Michael S Ip
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • David Sarraf
    Jules Stein Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Yuhua Zhang
    Doheny Eye Institute, Los Angeles, California, United States
    Ophthalmology, University of California Los Angeles, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Sujin Hoshi Nipro, Machida, logic and design, Code C (Consultant/Contractor), Alcon Japan, Code F (Financial Support), 2017-121307, Code P (Patent); Xiaolin Wang None; Shin Kadomoto None; Ruixue Liu None; Michael Ip Boehringer Ingelheim, Thrombogenics, Quark, Omeros, Allergan, Amgen, Astellas, Alimera, Code C (Consultant/Contractor), Novartis, Gnentech, Clearside, Biogen, Code F (Financial Support); David Sarraf Amgen, Bayer, Boehringer, Genentech, Heidelberg, Iverc Bio, Novartis, Optovue, Regeneron, Topcon, Code C (Consultant/Contractor); Srinivas Sadda Amgen, Allergan, Genentech/Roche, Iveric, Oxurion, Novartis, Regeneron, Bayer, 4DMT, Centervue, Heidelberg, Optos, Merck, Apellis, Astellas, Code C (Consultant/Contractor), Carl Zeiss Meditec, Nidek, Code R (Recipient), Nidek, Topcon, Heidelberg, Carl Zeiss Meditec, Optos, Centervue, Code R (Recipient); Yuhua Zhang None
  • Footnotes
    Support  The National Institute of Health (R01EY024378), W. F. Keck Foundation, Carl Marshall Reeves & Mildred Almen Reeves foundation, Research to Prevent Blindness/Dr. H. James and Carole Free Catalyst Award for Innovative Research Approaches for AMD.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2583 – F0466. doi:
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    • Get Citation

      Sujin Hoshi, Xiaolin Wang, Shin Kadomoto, Ruixue Liu, Michael S Ip, David Sarraf, Srinivas R Sadda, Yuhua Zhang; Adaptive optics scanning laser ophthalmoscopy of photoreceptor structure perturbation by acquired vitelliform lesions. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2583 – F0466.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : An acquired vitelliform lesion (AVL) is a retinal abnormality characterized by the accumulation of yellowish hyperfluorescent material in the subretinal space, but its impact on photoreceptor anatomy is incompletely understood. This study aimed to examine cone photoreceptor structure in eyes with AVL using multi-modal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO).

Methods : This was a retrospective study of subjects with AVL associated with age-related macular degeneration and adult-onset foveomacular vitelliform dystrophy. Subjects underwent color fundus photography (CFP), en-face infrared reflectance (IR), blue-light reflectance (BR) and autofluorescence (AF) imaging, and spectral-domain volume optical coherence tomography (SD-OCT) of the central macular. AVL was diagnosed based on the characteristic hyper-reflective subretinal material, anterior to the retinal pigment epithelium, with en face and cross-sectional OCT. Photoreceptor structure near the AVL was examined by AOSLO.

Results : AVL was found in a total of 28 eyes of 27 subjects, aged 77.7 ± 6.5 years. All subjects were white non-Hispanic and 14 were female, with mean Snellen visual acuity of 0.25 ± 0.37 (LogMAR, Snellen equivalent:). AOSLO revealed the cone mosaic disruption with apparently decreased cell density and lost or altered (hyper or hypo) reflectivity in the AVL affected areas. (Figure)

Conclusions : AOSLO imaging of cone photoreceptors near AVLs indicate that photoreceptor degeneration may be associated with AVL development. Because AVL represents a high-risk marker for atrophic or neovascular events that lead to significant vision loss, in vivo characterization of photoreceptor status in areas affected by AVL is important for a better understanding of disease pathophysiology and for the development of interventional trials.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

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