Abstract
Purpose :
24-2C SITA Standard is a prototype visual field (VF) test using the 24-2C test pattern, which added 10 new test locations to the 24-2. In this clinical study, we explored the diagnostic efficacy of global summary indices derived from 24-2C SITA Standard in a preliminary cohort of normal and glaucomatous eyes.
Methods :
24-2C SITA Standard (SS-C) and 24-2C SITA Faster (SFR-C) VFs were acquired on an HFA3 perimeter (ZEISS, Dublin, CA) at each of two visits on one eye of a group of 32 normal and 34 glaucomatous subjects. 24-2 SITA Standard (SS) and 24-2 SITA Faster (SFR) VFs were extracted from 24-2C VFs. The last qualified test for each VF was used for data analyses. The diagnostic performance for the VF global indices of Mean Deviation (MD), Visual Field Index (VFI) and Pattern Standard Deviation (PSD) was assessed using the area under the receiver operator characteristic curve (AROC) and sensitivity. AROCs were compared to those of SS and SS-C.
Results :
Mean age was 58.1 (standard deviation, SD: 7.6; range: 44 to 75) years for normal subjects and 71.6 (SD: 9.2; range 53 to 98) years for glaucoma patients. Mean MDSS-C was 0.35 (SD: 1.02; range: -1.63 to 2.45) dB and -8.57 (SD: 8.15; range: -25.29 to 1.39) dB in normal and glaucomatous eyes (P<0.001), respectively (see Table 1). The AROC of MDSS-C was 0.95. Compared to MDSS-C, the AROCs for MDSS, MDSFR, and MDSFR-C were 0.94 (P=0.120), 0.94 (P=0.563), and 0.95 (P=0.889), as shown in Table 2. The sensitivities at 95% specificity were 82.0% (MDSS), 71.0% (MDSFR), 85.0% (MDSS-C), and 76.0% (MDSFR-C), respectively. The AROC of VFISS-C was 0.97. Compared to VFISS-C, the AROCs for VFISS, VFISFR, and VFISFR-C were 0.96 (P=0.799), 0.96 (P=0.881), and 0.96 (P=0.873), as shown in Table 2. The sensitivities at 95% specificity were 88.0% (VFISS), 88.0% (VFISFR), 88.0% (VFISS-C), and 85.0% (VFISFR-C), respectively. Similar results were observed for PSD.
Conclusions :
The findings in this preliminary cohort suggest that the new 24-2C SITA Standard global summary indices may have similar (non-inferior) diagnostic performance to those of the existing 24-2 and 24-2C SITA strategies. In terms of global summary indices, 24-2C SITA Standard may provide a reasonable clinical alternative to current clinical threshold strategies for the diagnosis of glaucoma.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.