June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Clinical and optical coherence tomography comparison between ocular surface squamous neoplasia and squamous metaplasia
Author Affiliations & Notes
  • Shanlee M Stevens
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Daniela Reyes-Capo
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Umangi Patel
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Vincent Tang
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Rayan Amer Abou Khzam
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Anjalee Choudhury
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Sander R Dubovy
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Carol L. Karp
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Anat Galor
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
    VA Miami Healthcare System, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Shanlee Stevens None; Daniela Reyes-Capo None; Umangi Patel None; Vincent Tang None; Rayan Abou Khzam None; Anjalee Choudhury None; Sander Dubovy None; Carol Karp None; Anat Galor None
  • Footnotes
    Support  Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences R&D (CSRD) I01 CX002015 (Dr. Galor) and Biomedical Laboratory R&D (BLRD) Service I01 BX004893 (Dr. Galor), Department of Defense Gulf War Illness Research Program (GWIRP) W81XWH-20-1-0579 (Dr. Galor) and Vision Research Program (VRP) W81XWH-20-1-0820 (Dr. Galor), National Eye Institute R01EY026174 (Dr. Galor) and R61EY032468 (Dr. Galor), NIH Center Core Grant P30EY014801 (institutional) and Research to Prevent Blindness Unrestricted Grant (institutional), Dr. Ronald and Alicia Lepke Grant, The Lee and Claire Hager Grant, The Robert Farr Family Grant, The Grant and Diana Stanton-Thornbrough ,The Robert Baer Family Grant, The Roberto and Antonia Menendez Grant, The Emilyn Page and Mark Feldberg Grant, The Calvin and Flavia Oak Support Fund, The Robert Farr Family Grant, The Jose Ferreira de Melo Grant, The Richard and Kathy Lesser Grant, The Honorable A. Jay Cristol Grant, The Michele and Ted Kaplan Grant and the Richard Azar Family Grant(institutional grants).
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1193 – A0193. doi:
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    • Get Citation

      Shanlee M Stevens, Daniela Reyes-Capo, Umangi Patel, Vincent Tang, Rayan Amer Abou Khzam, Anjalee Choudhury, Sander R Dubovy, Carol L. Karp, Anat Galor; Clinical and optical coherence tomography comparison between ocular surface squamous neoplasia and squamous metaplasia. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1193 – A0193.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the clinical characteristics and high-resolution optical coherence tomography (HR-OCT) findings between corneal squamous metaplasia and ocular surface squamous neoplasia (OSSN).

Methods : A retrospective case control study of eight patients, four with histologically confirmed squamous metaplasia and four with histologically confirmed OSSN, that presented to the Miami Veterans Administration Medical Center and Bascom Palmer Eye Institute between 2016 and 2020, was performed. Clinical characteristics, HR-OCT findings, and pathology were evaluated and compared.

Results : Four patients with squamous metaplasia and four with OSSN were evaluated. In the metaplasia group, 75% were male, two were white, and two were black. In the OSSN group, all four were white males. All lesions were opalescent and occurred at the limbus; however, the borders were more smooth and rounded in the metaplastic lesions compared to OSSN. HR-OCT findings were indistinguishable between the two groups. The attached figure compares the slit lamp photograph, HR-OCT, and pathology between a case with squamous metaplasia (top row) and a case with OSSN (bottom row).

Conclusions : There is overlap in clinical characteristics and HR-OCT findings between corneal squamous metaplasia and OSSN, highlighting one limitation of HR-OCT. As such, if a corneal opacity has some but not all HR-OCT findings of OSSN, squamous metaplasia should also be considered. A biopsy may be indicated to further evaluate and guide treatment.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

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