June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
High resolution optical coherence tomography in patients with age related macular degeneration
Author Affiliations & Notes
  • Oussama Habra
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Virgilia Henchoz
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Chantal Dysli
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Damian Jaggi
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Sebastian Wolf
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Martin Sebastian Zinkernagel
    Ophthalmology, Inselspital Universitatsspital Bern, Bern, Bern, Switzerland
  • Footnotes
    Commercial Relationships   Oussama Habra None; Virgilia Henchoz None; Chantal Dysli None; Damian Jaggi None; Sebastian Wolf Bayer Healthcare Pharmaceuticals, Code C (Consultant/Contractor), Chengdu Kanghong Biotechnology , Code C (Consultant/Contractor), Allergan, Code F (Financial Support), Bayer Healthcare Pharmaceuticals, Code F (Financial Support), Carl Zeiss Meditec , Code F (Financial Support), Roche, Code F (Financial Support), Heidelberg Engineering, Code F (Financial Support), Novartis Pharmaceuticals Corporation, Code F (Financial Support); Martin Zinkernagel Allergan, Code C (Consultant/Contractor), Bayer Healthcare Pharmaceuticals, Code C (Consultant/Contractor), Novartis Pharmaceuticals Corporation , Code C (Consultant/Contractor), Bayer Healthcare Pharmaceuticals, Code F (Financial Support), Boehringer Ingelheim , Code F (Financial Support), Novartis Pharmaceuticals Corporation , Code I (Personal Financial Interest), Heidelberg Engineering, Code R (Recipient), Carl Zeiss Meditec, Code R (Recipient)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1033 – F0280. doi:
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      Oussama Habra, Virgilia Henchoz, Chantal Dysli, Damian Jaggi, Sebastian Wolf, Martin Sebastian Zinkernagel; High resolution optical coherence tomography in patients with age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1033 – F0280.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The high-resolution optical coherence tomography (HighRes-OCT) is an improvement of the routinely used spectral-domain OCT (SD-OCT) with increased axial resolution in tissue from 7 to 3 μm and may provide new informations about ultrastructural changes in age related macular degeneration (AMD), especially in iRORA and cRORA (incomplete, complete retinal pigment epithelial, outer retinal atrophy). The aim of this study is to show how increased axial resolution in a novel HighRes-OCT can distinguish structures not detected with conventional OCT in AMD

Methods : The prospective observational pilot study is performed on 50 patients at different AMD stages. An OCT of the macula is performed with the SD-OCT (SPECTRALIS ©, Heidelberg Engineering, Heidelberg, Germany) and the investigational HighRes-OCT (SPECTRALIS ©, Heidelberg Engineering, Heidelberg, Germany). The scan patterns used are 20° x 20° volume scan with 49 sections and 25 ART frames (512 A-scans per B-scan). Two different retina specialists then qualitatively compare the images. The presence of iRORA and cRORA was evaluated according to the consensus definition for atrophy associated with AMD on OCT. The main parameters assessed were the presence or absence of choroidal hypertransmission, zone of attenuation and/or disruption of the retinal pigment epithelium. Furthermore, the hyperreflective foci 94+and the thinning of the outer plexiform layer above atrophy were also investigated.

Results : Our results show that increased axial resolution in HighRes-OCT reveals several features such as better visualization of the Bruch’s membrane complex and the photoreceptor inner segments as well as a better delimitation of the inner plexiform layer than in a SD-OCT image. In geographic atrophy, the hyperreflective foci are clearer and there is a striking thinning of the outer plexiform layer above atrophy compared with conventional OCT in both forms of RORA.

Conclusions : Increased axial resolution OCT provides a higher resolution and yields more information about anatomical features in patients with both, iRORA and cRORA. This new technology can improve the diagnosis precision and will reserve us exciting data.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

 

A 78 years old male patient with iRORA (indicated by *) in the context of AMD. Image on the left side = spectral-domain OCT (SD-OCT), on the right side = High resolution OCT (HighRes-OCT). HRF = hyperreflective foci. OPL = outer plexiform layer

A 78 years old male patient with iRORA (indicated by *) in the context of AMD. Image on the left side = spectral-domain OCT (SD-OCT), on the right side = High resolution OCT (HighRes-OCT). HRF = hyperreflective foci. OPL = outer plexiform layer

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